TY - JOUR
T1 - Eight arm maze for mice
AU - Pick, Chaim G.
AU - Yanai, Joseph
N1 - Funding Information:
This study was supported by USPHS grant DA 2365.
PY - 1983
Y1 - 1983
N2 - Certain behaviors have been found to be mediated by the brain. Eight-arm maze behavior is a measure of spatial-memory, and the integrity of this has been connected with the integrity of the hippocampus in rats (Olton & Samuelson, 1976). Mice are useful animals in neuropharmacological research, but an apparatus for mice has not yet been developed, perhaps because mice were thought incapable of executing intricate tasks as compared with rats. We developed an eight-arm-maze adapted for mice to be used for such an experiment and also developed a procedure that was found to be highly useful and easy for mice to carry out, in order to increase their motivation to work in the apparatus. In our early studies we had shown that neonatal exposure to phenobarbital destroyed hippocampal neurons (Yanai & Bergman, 1981). Consequently, we used a sensitive eight-arm-maze to show that even small differences in performance can be clearly shown in this maze.
AB - Certain behaviors have been found to be mediated by the brain. Eight-arm maze behavior is a measure of spatial-memory, and the integrity of this has been connected with the integrity of the hippocampus in rats (Olton & Samuelson, 1976). Mice are useful animals in neuropharmacological research, but an apparatus for mice has not yet been developed, perhaps because mice were thought incapable of executing intricate tasks as compared with rats. We developed an eight-arm-maze adapted for mice to be used for such an experiment and also developed a procedure that was found to be highly useful and easy for mice to carry out, in order to increase their motivation to work in the apparatus. In our early studies we had shown that neonatal exposure to phenobarbital destroyed hippocampal neurons (Yanai & Bergman, 1981). Consequently, we used a sensitive eight-arm-maze to show that even small differences in performance can be clearly shown in this maze.
UR - http://www.scopus.com/inward/record.url?scp=0021075892&partnerID=8YFLogxK
U2 - 10.3109/00207458308986121
DO - 10.3109/00207458308986121
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AN - SCOPUS:0021075892
SN - 0020-7454
VL - 21
SP - 63
EP - 66
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 1-2
ER -