@article{9f9446651bd142669b2fe15e08896dc2,
title = "EGF receptor family: Twisting targets for improved cancer therapies",
abstract = "The epidermal growth factor receptor (EGFR) undergoes a conformational change in response to ligand binding. The ligand-induced changes in cell surface aggregation and mobility have a profound effect on the function of all the family members. Ligand also activates the EGFR intracellular kinase, stimulating proliferation and cell survival. The EGFR family are often activated, overexpressed or mutated in cancer cells and therapeutic drugs (including antibodies) can slow the progress of some cancers. This article provides a brief, annotated summary of the presentations and discussion which occurred at the Epidermal Growth Factor Receptor-Future Directions Conference held in Jerusalem in November 2013.",
keywords = "Cell surface, ErbB2, ErbB3, FLIM, FRET, Receptor dynamics, Therapeutic antibodies",
author = "Burgess, {Antony W.} and Henis, {Yoav I.} and Hynes, {Nancy E.} and Thomas Jovin and Alexander Levitzki and Ronit Pinkas-Kramarski and Yosef Yarden",
note = "Funding Information: The Institute for Advanced Studies and the Israel Science Foundation, Eli Lilly and Genentech Inc. provided the generous financial support which made the conference possible.",
year = "2014",
month = apr,
doi = "10.3109/08977194.2014.896355",
language = "אנגלית",
volume = "32",
pages = "74--81",
journal = "Growth Factors",
issn = "0897-7194",
publisher = "Informa Healthcare",
number = "2",
}
