Efficient procedure and methods to determine critical electroporation parameters

Gaddi Blumrosen*, Alireza Abazari, Alexander Golberg, Mehmet Tonner, Martin L. Yarmush

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

9 Scopus citations

Abstract

Controlling electroporation and determination of its design parameters govern the performance in many electroporation applications in the fields of medicine, biology, and food industry. This work provides an enhanced high throughput signal processing method to enable non-expert, objective, automatic and fast analysis of large datasets of microscopic images of high throughput electroporation experiments. This can enable optimal design of vital electroporation parameters including the optimal thresholds for the electric field strength, and the optimal number of pulses. In this work the non-expert visualization platform and the methods are described, and implemented on normal dermal human fibroblasts cell culture.

Original languageEnglish
Title of host publicationProceedings - 2014 IEEE 27th International Symposium on Computer-Based Medical Systems, CBMS 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages314-318
Number of pages5
ISBN (Print)9781479944354
DOIs
StatePublished - 2014
Externally publishedYes
Event27th IEEE International Symposium on Computer-Based Medical Systems, CBMS 2014 - New York, NY, United States
Duration: 27 May 201429 May 2014

Publication series

NameProceedings - IEEE Symposium on Computer-Based Medical Systems
ISSN (Print)1063-7125

Conference

Conference27th IEEE International Symposium on Computer-Based Medical Systems, CBMS 2014
Country/TerritoryUnited States
CityNew York, NY
Period27/05/1429/05/14

Keywords

  • Biological system modeling
  • Electroporation
  • Image processing
  • Light Microscopy
  • clustering

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