Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study

Ophir Gilad*, Guy Rosner, Dana Ivancovsky-Wajcman, Reut Zur, Rina Rosin-Arbesfeld, Nathan Gluck, Hana Strul, Dana Lehavi, Vivien Rolfe, Revital Kariv

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Several studies have demonstrated that curcumin can cause the regression of polyps in familial adenomatous polyposis (FAP), while others have shown negative results. Wholistic turmeric (WT) containing curcumin and additional bioactive compounds may contribute to this effect. We performed a double-blinded, randomized, controlled trial to assess the efficacy of WT in FAP patients. Ten FAP patients were randomly assigned to receive either WT or placebo for 6 months. Colonoscopies were performed at baseline and after 6 months. The polyp number and size, as well as the cumulative polyp burden, were assessed. No differences were noted between the groups in terms of changes from the baseline’s polyp number, size, or burden. However, stratifying the data according to the right vs. left colon indicated a decrease in the median polyp number (from 5.5 to 1.5, p = 0.06) and polyp burden (from 24.25 mm to 11.5 mm, p = 0.028) in the left colon of the patients in the WT group. The adjusted left polyp number and burden in the WT arm were lower by 5.39 (p = 0.034) and 14.68 mm (p = 0.059), respectively. Whether WT can be used to reduce the polyp burden of patients with predominantly left-sided polyps remains to be seen; thus, further larger prospective trials are required.

Original languageEnglish
Article number2182
JournalGenes
Volume13
Issue number12
DOIs
StatePublished - Dec 2022

Keywords

  • chemoprevention
  • curcumin
  • familial adenomatous polyposis
  • turmeric

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