Efficacy of thrombolysis is determined by hemodynamic factors: results from an in-vitro flow model

Uri Zaretsky; Shmuel Einav; Lev Mendelevich; Gad Keren

Efficacy of thrombolysis is determined by hemodynamic factors: results from an in-vitro flow model

Uri Zaretsky^*, Shmuel Einav, Lev Mendelevich, Gad Keren

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to conference › Paper › peer-review

Abstract

A study was made to determine whether changes in perfusion pressure in an in-vitro model could affect the time to thrombolysis. Fresh blood was obtained from six normal healthy volunteers lacking any drug treatment. Thrombi were then subjected to one of four groups. Recanalization time was calculated as the time interval elapsed from the moment administration to flow restoration. The data from the study suggests that(1) the hemodynamic factors determine the efficacy of streptokinase induced thrombolysis, and (2) spontaneous clot lysis is more likely to occur at higher perfusion pressure.

Original language	English
Pages	529-530
Number of pages	2
State	Published - 1997
Event	Proceedings of the 1997 Bioengineering Conference - Sunriver, OR, USA Duration: 11 Jun 1997 → 15 Jun 1997

Conference

Conference	Proceedings of the 1997 Bioengineering Conference
City	Sunriver, OR, USA
Period	11/06/97 → 15/06/97

Cite this

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abstract = "A study was made to determine whether changes in perfusion pressure in an in-vitro model could affect the time to thrombolysis. Fresh blood was obtained from six normal healthy volunteers lacking any drug treatment. Thrombi were then subjected to one of four groups. Recanalization time was calculated as the time interval elapsed from the moment administration to flow restoration. The data from the study suggests that(1) the hemodynamic factors determine the efficacy of streptokinase induced thrombolysis, and (2) spontaneous clot lysis is more likely to occur at higher perfusion pressure.",

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AU - Zaretsky, Uri

AU - Einav, Shmuel

AU - Mendelevich, Lev

AU - Keren, Gad

PY - 1997

Y1 - 1997

N2 - A study was made to determine whether changes in perfusion pressure in an in-vitro model could affect the time to thrombolysis. Fresh blood was obtained from six normal healthy volunteers lacking any drug treatment. Thrombi were then subjected to one of four groups. Recanalization time was calculated as the time interval elapsed from the moment administration to flow restoration. The data from the study suggests that(1) the hemodynamic factors determine the efficacy of streptokinase induced thrombolysis, and (2) spontaneous clot lysis is more likely to occur at higher perfusion pressure.

AB - A study was made to determine whether changes in perfusion pressure in an in-vitro model could affect the time to thrombolysis. Fresh blood was obtained from six normal healthy volunteers lacking any drug treatment. Thrombi were then subjected to one of four groups. Recanalization time was calculated as the time interval elapsed from the moment administration to flow restoration. The data from the study suggests that(1) the hemodynamic factors determine the efficacy of streptokinase induced thrombolysis, and (2) spontaneous clot lysis is more likely to occur at higher perfusion pressure.

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Y2 - 11 June 1997 through 15 June 1997

ER -

Efficacy of thrombolysis is determined by hemodynamic factors: results from an in-vitro flow model

Abstract

Conference

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