Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

Peter L. DeMarsh, Scott K. Sucoloski, Carrie L. Frey, Pradip K. Bhatnagar, Yigal Koltin, Paul Actor, Stephen R. Petteway

Research output: Contribution to journalArticlepeer-review

Abstract

SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalImmunopharmacology
Volume27
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Candida albicans
  • Hematoregulatory
  • SK&F 107647

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