Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

Peter L. DeMarsh; Scott K. Sucoloski; Carrie L. Frey; Pradip K. Bhatnagar; Yigal Koltin; Paul Actor; Stephen R. Petteway

doi:10.1016/0162-3109(94)90016-7

Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

Peter L. DeMarsh^*, Scott K. Sucoloski, Carrie L. Frey, Pradip K. Bhatnagar, Yigal Koltin, Paul Actor, Stephen R. Petteway

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

Original language	English
Pages (from-to)	199-206
Number of pages	8
Journal	Immunopharmacology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/0162-3109(94)90016-7
State	Published - 1994
Externally published	Yes

Keywords

Candida albicans
Hematoregulatory
SK&F 107647

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10.1016/0162-3109(94)90016-7

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title = "Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice",

abstract = "SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu {"}nude{"} mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).",

keywords = "Candida albicans, Hematoregulatory, SK&F 107647",

author = "DeMarsh, {Peter L.} and Sucoloski, {Scott K.} and Frey, {Carrie L.} and Bhatnagar, {Pradip K.} and Yigal Koltin and Paul Actor and Petteway, {Stephen R.}",

year = "1994",

doi = "10.1016/0162-3109(94)90016-7",

language = "אנגלית",

volume = "27",

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journal = "Immunopharmacology",

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AU - DeMarsh, Peter L.

AU - Sucoloski, Scott K.

AU - Frey, Carrie L.

AU - Bhatnagar, Pradip K.

AU - Koltin, Yigal

AU - Actor, Paul

AU - Petteway, Stephen R.

PY - 1994

Y1 - 1994

N2 - SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

AB - SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

KW - Candida albicans

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JO - Immunopharmacology

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Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

Abstract

Keywords

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