Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

Peter L. DeMarsh*, Scott K. Sucoloski, Carrie L. Frey, Pradip K. Bhatnagar, Yigal Koltin, Paul Actor, Stephen R. Petteway

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalImmunopharmacology
Volume27
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Candida albicans
  • Hematoregulatory
  • SK&F 107647

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