Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

Peter L. DeMarsh; Scott K. Sucoloski; Carrie L. Frey; Pradip K. Bhatnagar; Yigal Koltin; Paul Actor; Stephen R. Petteway

doi:10.1016/0162-3109(94)90016-7

Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

Peter L. DeMarsh, Scott K. Sucoloski, Carrie L. Frey, Pradip K. Bhatnagar, Yigal Koltin, Paul Actor, Stephen R. Petteway

Research output: Contribution to journal › Article › peer-review

Abstract

SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

Original language	English
Pages (from-to)	199-206
Number of pages	8
Journal	Immunopharmacology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/0162-3109(94)90016-7
State	Published - 1994
Externally published	Yes

Keywords

Candida albicans
Hematoregulatory
SK&F 107647

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10.1016/0162-3109(94)90016-7

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title = "Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice",

abstract = "SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu {"}nude{"} mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).",

keywords = "Candida albicans, Hematoregulatory, SK&F 107647",

author = "DeMarsh, {Peter L.} and Sucoloski, {Scott K.} and Frey, {Carrie L.} and Bhatnagar, {Pradip K.} and Yigal Koltin and Paul Actor and Petteway, {Stephen R.}",

year = "1994",

doi = "10.1016/0162-3109(94)90016-7",

language = "אנגלית",

volume = "27",

pages = "199--206",

journal = "Immunopharmacology",

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publisher = "Elsevier BV",

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AU - DeMarsh, Peter L.

AU - Sucoloski, Scott K.

AU - Frey, Carrie L.

AU - Bhatnagar, Pradip K.

AU - Koltin, Yigal

AU - Actor, Paul

AU - Petteway, Stephen R.

PY - 1994

Y1 - 1994

N2 - SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

AB - SK&F 107647, a novel synthetic dimetric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in γ irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.).

KW - Candida albicans

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KW - SK&F 107647

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JO - Immunopharmacology

JF - Immunopharmacology

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ER -

Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systematic Candida albicans infections in normal and immunosuppressed mice

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Keywords

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