Die wirksamkeit niedrigdosierter einzelgabe von methylphenidat bei erwachsenen ADHD-patienten

Translated title of the contribution: Efficacy of single low-dose methylphenidate administration in adult ADHD patients according to psychometric assessment

Iris Manor, Richard P. Ebstein, Abraham Weizman, Sam Tyano

Research output: Contribution to journalArticlepeer-review

Abstract

Attention deficit hyperactivity disorder (ADHD) is a chronic disabling disorder that often persists to adulthood (70%). Methylphenidate (MPH) is reported efficient in adults suffering from ADHD. MPH dosage of ∼0.5mg/Kg is common in children and adolescents. MPH dosage in adults is not determined and upper limit of 1mg/kg(1) was recommended. Objective: To evaluate the efficacious dosage of MPH in adults. Method: Adult ADHD/ADD patients who responded to MPH, according to the Test of Variables of Attention (T.O.V.A), were included. Response was estimated by repeating T.O.V.A.(2). The dose, 15mg/20mg, was weight dependent (</≥80Kg). Results: 42/47 diagnosed adults had good response to MPH. Mean age 31.8±9.0, M:F ratio 21:21, ADHD/ADD 20:22. Highest dose 0.35 mg/Kg. Mean dosage was 0.2±0.05mg/Kg with a significant improvement in all T.O.V.A. scores: ADHD scores (p<0.0001); Standard Scores (p 0.02-0.001). The most effective dosage was 0.2-0.25mg/Kg (p≤0.001). Commission score, which correlates to impulsivity, showed the least improvement under MPH treatment, and was aggrevated at higher doses (T= -0.16, p=0.88). Conclusions: Low doses of MPH seem to be efficient in adults according to the improvement in T.O.V.A., while higher dosages may correlate with side effects.

Translated title of the contributionEfficacy of single low-dose methylphenidate administration in adult ADHD patients according to psychometric assessment
Original languageGerman
Pages (from-to)75-88
Number of pages14
JournalDynamische Psychiatrie
Volume36
Issue number1-2
StatePublished - 2003

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