Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae

I. Shalit; A. Barnea; A. Shahar

doi:10.1128/AAC.33.5.788

Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae

I. Shalit, A. Barnea, A. Shahar

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Research output: Contribution to journal › Article › peer-review

Abstract

Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 μg/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10⁶ leptospires. In contrast, five of six animals given ciprofloxacin 3 or 5 days after challenge survived.

Original language	English
Pages (from-to)	788-789
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	33
Issue number	5
DOIs	https://doi.org/10.1128/AAC.33.5.788
State	Published - 1989

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10.1128/AAC.33.5.788

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abstract = "Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 μg/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 106 leptospires. In contrast, five of six animals given ciprofloxacin 3 or 5 days after challenge survived.",

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Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae

Abstract

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