@article{56b2e8ce4c544f07b34518af331722ee,
title = "Efficacy of BGJ398, a fibroblast growth factor receptor 1–3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations",
abstract = "BGJ398, a potent and selective pan-FGFR antagonist, was prospectively evaluated in patients with metastatic urothelial carcinoma bearing a diverse array of FGFR3 alterations. Patients (N = 67) who were unable to receive platinum chemotherapy were enrolled. The majority (70.1%) had received two or more prior antineoplastic therapies. BGJ398 was administered orally at 125 mg/day on a 3 weeks on, 1 week off schedule until unacceptable toxicity or progression. The primary endpoint was the response rate. Among 67 patients treated, an overall response rate of 25.4% was observed and an additional 38.8% of patients had disease stabilization, translating to a disease control rate of 64.2%. The most common treatment-emergent toxicities were hyperphosphatemia, elevated creatinine, fatigue, constipation, and decreased appetite. Further examination of BGJ398 in this disease setting is warranted. SIGnIFICAnCE: BJG398 is active in patients with alterations in FGFR3, resulting in both reductions in tumor volume and stabilization of disease. Our data highlight putative mechanisms of resistance to the agent, which may be useful in following disease status.",
author = "Pal, {Sumanta K.} and Rosenberg, {Jonathan E.} and Hoffman-Censits, {Jean H.} and Raanan Berger and Quinn, {David I.} and Galsky, {Matthew D.} and Juergen Wolf and Christian Dittrich and Bhumsuk Keam and Delord, {Jean Pierre} and Schellens, {Jan H.M.} and Gwenaelle Gravis and Jacques Medioni and Pablo Maroto and Virote Sriuranpong and Chaiyut Charoentum and Burris, {Howard A.} and Viktor Gr{\"u}nwald and Daniel Petrylak and Ulka Vaishampayan and Eliahu Gez and {De Giorgi}, Ugo and Lee, {Jae Lyun} and Jens Voortman and Sumati Gupta and Sunil Sharma and Amir Mortazavi and Vaughn, {David J.} and Randi Isaacs and Katie Parker and Xueying Chen and Kun Yu and Dale Porter and Porta, {Diana Graus} and Bajorin, {Dean F.}",
note = "Publisher Copyright: {\textcopyright} 2018 American Association for Cancer Research.",
year = "2018",
month = jul,
doi = "10.1158/2159-8290.CD-18-0229",
language = "אנגלית",
volume = "8",
pages = "812--821",
journal = "Cancer Discovery",
issn = "2159-8274",
publisher = "American Association for Cancer Research Inc.",
number = "7",
}
