Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart

Amir Pelleg, Yosef Pardo, Bernard Belhassen, Boris Shargordsky, Avri Chagnac, Shlomo Laniado

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF) were studied in a canine model. The control group consisted of 27 dogs. 30 dogs received intravenous verapamil (0.2 mg/kg/3 min followed by a continuous infusion of 0.01 mg/kg/min for 15 min). 18 dogs received bepridil (0.5 mg/kg/min for 10 min). The left anterior descending coronary artery was occluded in one step 8 min after the commencement of verapamil administration and 5 min after the termination of bepridil infusion. The incidence of ventricular arrhythmias during the occlusion period was 14 (VF, 5/14), 13 (VF, 0/13) and 14 (VF, 9/14) in the control, verapamil and bepridil groups, respectively. The frequencies of reperfusion VF were 8/24 (33%), 4/30 (13.3%) and 0/13 (0%), respectively. It was concluded that (a) verapamil effectively prevents occlusion but not reperfusion VF and (b) bepridil has an arrhythmogenic effect in the ischemic canine heart but reduces the incidence of reperfusion VF.

Original languageEnglish
Pages (from-to)193-201
Number of pages9
JournalCardiology
Volume72
Issue number4
DOIs
StatePublished - 1985
Externally publishedYes

Keywords

  • Bepridil
  • Occlusion arrhythmias
  • Reperfusion arrhythmias
  • Verapamil

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