Effects of sodium loading on the renal synthesis of prostanoids in the rat

M. Rathaus, E. Podjarny, J. Shapira, N. Kariv, J. Bernheim

Research output: Contribution to journalArticlepeer-review

Abstract

The production of prostaglandin (PG) E2, F(2α) and thromboxane B2 (TXB2) by isolated glomeruli, cortical tubular suspensions and medullary and papillary slices was measured in normal Long-Evans rats 4, 8 and 14 days after starting on oral Na+ load and the results were compared with those of rats on a normal Na+ intake. In glomeruli, PGE2 decreased at days 4 and 8, and returned to normal at 14 days. PGF(2α) decreased only at day 4 and TXB2 decreased in all Na+-loaded animals. In cortical suspensions, a transient decrease of PGE2 was observed at day 4. In medullary slices, PGE2 and TXB2 decreased in all experimental periods. In contrast, in papillae, a significant increase of PGE2 was observed with Na+ loading at day 8, but PGF(2α) and TXB2 did not change consistently. Similar changes were observed in rats with hypothalamic diabetes insipidus (DI rats) Na+ loaded for 4 days, as compared with DI rats on a normal Na+ intake. The results suggest that prostanoids participate in the renal adaptation to an increased Na+ intake, and that this response is relatively independent of the presence of antidiuretic hormone

Original languageEnglish
Pages (from-to)653-657
Number of pages5
JournalClinical Science
Volume73
Issue number6
DOIs
StatePublished - 1987
Externally publishedYes

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