TY - JOUR
T1 - Effects of prolonged lithium treatment on the water consumption and lithium content of rats
AU - Zilberman, Yael
AU - Kapitulnik, Jaime
AU - Feuerstein, Giora
AU - Lichtenberg, Dov
PY - 1979/6
Y1 - 1979/6
N2 - Injection of LiC1 to rats (3.0 mmole/kg/day) caused a marked increase in water intake. The polydipsic effect was maximal after 8 - 10 days of treatment and then gradually declined. This reduction in polydipsia was accompanied by a decrease in Li+ content of plasma, red blood cells, liver, spleen, kidney and brain. Furthermore, the ratio of tissue to plasma lithium concentration (lithium index) declined in all tissues examined. The decrease in polydipsia was abolished by increasing the dose of LiC1 by 50%. These results suggest that tolerance to the polydipsic effect of lithium develops in the rat during chronic treatment with LiC1 as a result of a reduction in the cells capacity to accumulate lithium.
AB - Injection of LiC1 to rats (3.0 mmole/kg/day) caused a marked increase in water intake. The polydipsic effect was maximal after 8 - 10 days of treatment and then gradually declined. This reduction in polydipsia was accompanied by a decrease in Li+ content of plasma, red blood cells, liver, spleen, kidney and brain. Furthermore, the ratio of tissue to plasma lithium concentration (lithium index) declined in all tissues examined. The decrease in polydipsia was abolished by increasing the dose of LiC1 by 50%. These results suggest that tolerance to the polydipsic effect of lithium develops in the rat during chronic treatment with LiC1 as a result of a reduction in the cells capacity to accumulate lithium.
UR - http://www.scopus.com/inward/record.url?scp=0018647968&partnerID=8YFLogxK
U2 - 10.1016/S0031-6989(79)80018-1
DO - 10.1016/S0031-6989(79)80018-1
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0018647968
SN - 0031-6989
VL - 11
SP - 467
EP - 474
JO - Pharmacological Research Communications
JF - Pharmacological Research Communications
IS - 6
ER -