Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males

Nurit Rosenberg, Ariella Zivelin, Angela Chetrit, Rima Dardik, Nurit Kornbrot, Dov Freimark, Aida Inbal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPIa/IIa, GPIbα, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction. Objective: To evaluate the risks exerted by each of the following polymorphisms in young males with AMI: HPA-1a/b in GPIIIa; 807C/T in GPIa; and HPA-2a/b, VNTR and Kozak C/T in GPIbα. Methods: We conducted a case-control study of 100 young males with first AMI before the age of 53 and 119 healthy controls of similar age. All subjects were tested for the above polymorphisms. Results: The allele frequencies of each of the platelet polymorphisms were not significantly different between the young men with AMI and the controls. Smoking alone was associated with a 9.97-fold risk, and the presence of at least one metabolic risk factor resulted in a 2.57-fold risk of AMI. Conclusion: The platelet glycoproteins polymorphisms studied are not an independent risk factor for AMI.

Original languageEnglish
Pages (from-to)411-414
Number of pages4
JournalIsrael Medical Association Journal
Volume4
Issue number6
StatePublished - 2002
Externally publishedYes

Keywords

  • GPIIIa
  • GPIa
  • GPIb
  • Myocardial infarction
  • Platelet polymorphisms

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