TY - JOUR
T1 - Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males
AU - Rosenberg, Nurit
AU - Zivelin, Ariella
AU - Chetrit, Angela
AU - Dardik, Rima
AU - Kornbrot, Nurit
AU - Freimark, Dov
AU - Inbal, Aida
PY - 2002
Y1 - 2002
N2 - Background: Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPIa/IIa, GPIbα, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction. Objective: To evaluate the risks exerted by each of the following polymorphisms in young males with AMI: HPA-1a/b in GPIIIa; 807C/T in GPIa; and HPA-2a/b, VNTR and Kozak C/T in GPIbα. Methods: We conducted a case-control study of 100 young males with first AMI before the age of 53 and 119 healthy controls of similar age. All subjects were tested for the above polymorphisms. Results: The allele frequencies of each of the platelet polymorphisms were not significantly different between the young men with AMI and the controls. Smoking alone was associated with a 9.97-fold risk, and the presence of at least one metabolic risk factor resulted in a 2.57-fold risk of AMI. Conclusion: The platelet glycoproteins polymorphisms studied are not an independent risk factor for AMI.
AB - Background: Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPIa/IIa, GPIbα, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction. Objective: To evaluate the risks exerted by each of the following polymorphisms in young males with AMI: HPA-1a/b in GPIIIa; 807C/T in GPIa; and HPA-2a/b, VNTR and Kozak C/T in GPIbα. Methods: We conducted a case-control study of 100 young males with first AMI before the age of 53 and 119 healthy controls of similar age. All subjects were tested for the above polymorphisms. Results: The allele frequencies of each of the platelet polymorphisms were not significantly different between the young men with AMI and the controls. Smoking alone was associated with a 9.97-fold risk, and the presence of at least one metabolic risk factor resulted in a 2.57-fold risk of AMI. Conclusion: The platelet glycoproteins polymorphisms studied are not an independent risk factor for AMI.
KW - GPIIIa
KW - GPIa
KW - GPIb
KW - Myocardial infarction
KW - Platelet polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=0036285134&partnerID=8YFLogxK
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AN - SCOPUS:0036285134
SN - 1565-1088
VL - 4
SP - 411
EP - 414
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 6
ER -