Effects of peri-implant infection on serum biochemical analysis

Liat Chaushu*, Haim Tal, Anton Sculean, Blanca Fernández-Tomé, Gavriel Chaushu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Peri-implant disease (PID) has not been directly linked to pathological organ changes. The present study assessed the dynamics of serum biochemical parameters in a model of experimental peri-implantitis in dogs, followed by open flap debridement. Methods: Seven male beagle dogs comprised the study group. Procedures were performed as follows—extractions of two premolars and one molar on each mandibular quadrant (Day 0); bone healing time (week14); placement of four rough-surface endoosseous implants, two on each mandibular side; implant uncovering (week 28); induction of experimental peri-implantitis by the use of three ligatures (weeks 31, 34, 37) followed by open flap debridement (week 42). Serum biochemical analysis following each procedure was compared to baseline. Biochemical parameters were assigned into four subsets of variables—inflammation, renal function, liver function, and blood glucose. Wilcoxon paired tests were conducted in order to identify statistically significant differences between baseline data and values obtained after each procedure. Results: Following experimental peri-implantitis, the dynamics of renal parameters and blood glucose were minimal whereas statistically significant (P < 0.05) increases were noted for inflammatory (total protein and albumin concentrations) and hepatic (ALT, AST) parameters. A statistically significant (P < 0.05) decrease was only noted for total bilirubin. After open flap debridement, inflammatory (total protein and albumin concentrations) and hepatic (AST) parameters returned to baseline. Conclusions: Within their limits, the present results indicate that: (a) PID affects inflammatory and hepatic serum biochemical parameters, and (b) following open flap debridement most of the values returned to baseline.

Original languageEnglish
Pages (from-to)436-445
Number of pages10
JournalJournal of Periodontology
Issue number3
StatePublished - Mar 2021


  • biochemical analysis
  • infection
  • inflammation
  • peri-implant disease
  • systemic disease


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