TY - JOUR
T1 - Effects of Parkinson's disease on brain-wave phase synchronisation and cross-modulation
AU - Stumpf, K.
AU - Schumann, A. Y.
AU - Plotnik, M.
AU - Gans, F.
AU - Penzel, T.
AU - Fietze, I.
AU - Hausdorff, J. M.
AU - Kantelhardt, J. W.
PY - 2010
Y1 - 2010
N2 - We study the effects of Parkinson's disease (PD) on phase synchronisation and cross-modulation of instantaneous amplitudes and frequencies for brain waves during sleep. Analysing data from 40 full-night EEGs (electro-encephalograms) of ten patients with PD and ten age-matched healthy controls we find that phase synchronisation between the left and right hemisphere of the brain is characteristically reduced in patients with PD. Since there is no such difference in phase synchronisation for EEGs from the same hemisphere, our results suggest the possibility of a relation with problems in coordinated motion of left and right limbs in some patients with PD. Using the novel technique of amplitude and frequency cross-modulation analysis, relating oscillations in different EEG bands and distinguishing both positive and negative modulation, we observe an even more significant decrease in patients for several band combinations.
AB - We study the effects of Parkinson's disease (PD) on phase synchronisation and cross-modulation of instantaneous amplitudes and frequencies for brain waves during sleep. Analysing data from 40 full-night EEGs (electro-encephalograms) of ten patients with PD and ten age-matched healthy controls we find that phase synchronisation between the left and right hemisphere of the brain is characteristically reduced in patients with PD. Since there is no such difference in phase synchronisation for EEGs from the same hemisphere, our results suggest the possibility of a relation with problems in coordinated motion of left and right limbs in some patients with PD. Using the novel technique of amplitude and frequency cross-modulation analysis, relating oscillations in different EEG bands and distinguishing both positive and negative modulation, we observe an even more significant decrease in patients for several band combinations.
UR - http://www.scopus.com/inward/record.url?scp=79051471492&partnerID=8YFLogxK
U2 - 10.1209/0295-5075/89/48001
DO - 10.1209/0295-5075/89/48001
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:79051471492
SN - 0295-5075
VL - 89
JO - Journal de Physique (Paris), Lettres
JF - Journal de Physique (Paris), Lettres
IS - 4
M1 - 48001
ER -