Effects of metoclopramide on plasma corticosteroid levels in sheep

James R. Sowers; Frances W.J. Beck; Naftali Stern; Norman Asp

doi:10.1210/endo-113-3-903

Effects of metoclopramide on plasma corticosteroid levels in sheep

James R. Sowers^*
, Frances W.J. Beck
, Naftali Stern
, Norman Asp

^*Corresponding author for this work

VA Medical Center

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

This study investigated the role of dopaminergic mechanisms in modulation of corticosteroid secretion in sheep. Administration of the dopamine antagonist metoclopramide (200 Mg/kg iv) in six mature sheep resulted in rapid and parallel rises in plasma cortisol, corticosterone, 18-hydroxycorticosterone, and aldosterone. Treatment of the sheep with 4 mg dexamethasone im every 6 h for 4 days abolished the response of all four corticosteroids to metoclopramide in the six sheep. These observations suggest that metoclopramide may stimulate corticosteroid secretion in sheep via nonspecific stressor effects (Endocrinology 113: 903, 1983).

Original language	English
Pages (from-to)	903-906
Number of pages	4
Journal	Endocrinology
Volume	113
Issue number	3
DOIs	https://doi.org/10.1210/endo-113-3-903
State	Published - Sep 1983
Externally published	Yes

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title = "Effects of metoclopramide on plasma corticosteroid levels in sheep",

abstract = "This study investigated the role of dopaminergic mechanisms in modulation of corticosteroid secretion in sheep. Administration of the dopamine antagonist metoclopramide (200 Mg/kg iv) in six mature sheep resulted in rapid and parallel rises in plasma cortisol, corticosterone, 18-hydroxycorticosterone, and aldosterone. Treatment of the sheep with 4 mg dexamethasone im every 6 h for 4 days abolished the response of all four corticosteroids to metoclopramide in the six sheep. These observations suggest that metoclopramide may stimulate corticosteroid secretion in sheep via nonspecific stressor effects (Endocrinology 113: 903, 1983).",

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Effects of metoclopramide on plasma corticosteroid levels in sheep

Abstract

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