TY - JOUR
T1 - Effects of methylprednisolone administration in acute myocardial infarction
AU - Vyden, John K.
AU - Nagasawa, Koichi
AU - Rabinowitz, Babeth
AU - Parmley, William W.
AU - Tomoda, Haruo
AU - Corday, Eliot
AU - Swan, H. J.C.
N1 - Funding Information:
From the Department of Cardiology, Cedars-Sinai Medical Center and the Department of Medicine, Universityo f California, Los Angeles, Los Angeles, Calif. This study was supported in part by Contract Pt+43-6&1333 under Myocardial infarction Research Program, NaMonal lnsti-tutes of Health, Bethesda, Md., and a grant from the Upjohn Company, Kalamazoo, Mich. Manu- script accepted March 27, 1974. ‘This work was done under the tenure of an Established InvestIgatorship of the American Heart Association. Address for reprints: Department of Cardblo-gy, Cedars-Sir&l Medical Center, 4833 Fountain Ave., Los Angeles, Callf. 90029.
PY - 1974/11
Y1 - 1974/11
N2 - Methylprednisolone sodium succinate, 50 mg/kg body weight, was given as an intravenous bolus injection to 15 dogs with acute myocardial infarction and the results were compared with data in control animals. Methylprednisolone was thought to improve the critical oxygen balance of the infarcted heart by two mechanisms: (1) by diminishing heart rate, afterload and preload in the initial 15 minutes after its administration and thereby decreasing the oxygen need of the heart, and (2) by increasing coronary arterial blood flow. Both mechanisms were believed to contribute to the increase in cardiac output, efficiency and ventricular performance. This improvement in performance was presumably not due to a positive inotropic effect, since studies in isolated heart muscle showed no effect of methylprednisolone on contractility. Regional circulations other than the coronary circulation seemed to be little affected by administration of methylprednisolone except for blood pressure-related increases in superior mesenteric and femoral arterial blood flow.
AB - Methylprednisolone sodium succinate, 50 mg/kg body weight, was given as an intravenous bolus injection to 15 dogs with acute myocardial infarction and the results were compared with data in control animals. Methylprednisolone was thought to improve the critical oxygen balance of the infarcted heart by two mechanisms: (1) by diminishing heart rate, afterload and preload in the initial 15 minutes after its administration and thereby decreasing the oxygen need of the heart, and (2) by increasing coronary arterial blood flow. Both mechanisms were believed to contribute to the increase in cardiac output, efficiency and ventricular performance. This improvement in performance was presumably not due to a positive inotropic effect, since studies in isolated heart muscle showed no effect of methylprednisolone on contractility. Regional circulations other than the coronary circulation seemed to be little affected by administration of methylprednisolone except for blood pressure-related increases in superior mesenteric and femoral arterial blood flow.
UR - http://www.scopus.com/inward/record.url?scp=0016288561&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(74)90157-X
DO - 10.1016/0002-9149(74)90157-X
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AN - SCOPUS:0016288561
SN - 0002-9149
VL - 34
SP - 677
EP - 686
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -
