Effects of methotrexate on radiologic progression in juvenile rheumatoid arthritis

Liora Harel; Linda Wagner‐Weiner; Andrew K. Poznanski; Charles H. Spencer; Edem Ekwo; Daniel B. Magilavy

doi:10.1002/art.1780361007

Effects of methotrexate on radiologic progression in juvenile rheumatoid arthritis

Liora Harel
, Linda Wagner‐Weiner^*
, Andrew K. Poznanski
, Charles H. Spencer
, Edem Ekwo
, Daniel B. Magilavy

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Objective. To assess the effects of methotrexate (MTX) therapy on radiologic progression in juvenile rheumatoid arthritis (JRA). Methods. We evaluated serial wrist radiographs for carpal length in 23 JRA patients with bilateral wrist involvement, before and during MTX treatment. These carpal length measurements were compared with established norms for carpal length in a healthy pediatric population. Results. Both clinical responders to MTX (17 of 23 patients) and nonresponders (6 of 23) had decreasing carpal length prior to initiation of the treatment. Eleven of the 17 clinical responders had improved carpal length after a mean of 2.5 years of MTX treatment. All 6 clinical nonresponders had progressive loss of carpal length. Conclusion. MTX treatment resulted in radiologic improvement, as measured by carpal length, in the majority of children with JRA who had a clinical response to MTX.

Original language	English
Pages (from-to)	1370-1374
Number of pages	5
Journal	Arthritis and Rheumatology
Volume	36
Issue number	10
DOIs	https://doi.org/10.1002/art.1780361007
State	Published - Oct 1993
Externally published	Yes

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title = "Effects of methotrexate on radiologic progression in juvenile rheumatoid arthritis",

abstract = "Objective. To assess the effects of methotrexate (MTX) therapy on radiologic progression in juvenile rheumatoid arthritis (JRA). Methods. We evaluated serial wrist radiographs for carpal length in 23 JRA patients with bilateral wrist involvement, before and during MTX treatment. These carpal length measurements were compared with established norms for carpal length in a healthy pediatric population. Results. Both clinical responders to MTX (17 of 23 patients) and nonresponders (6 of 23) had decreasing carpal length prior to initiation of the treatment. Eleven of the 17 clinical responders had improved carpal length after a mean of 2.5 years of MTX treatment. All 6 clinical nonresponders had progressive loss of carpal length. Conclusion. MTX treatment resulted in radiologic improvement, as measured by carpal length, in the majority of children with JRA who had a clinical response to MTX.",

author = "Liora Harel and Linda Wagner‐Weiner and Poznanski, \{Andrew K.\} and Spencer, \{Charles H.\} and Edem Ekwo and Magilavy, \{Daniel B.\}",

year = "1993",

month = oct,

doi = "10.1002/art.1780361007",

language = "אנגלית",

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pages = "1370--1374",

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T1 - Effects of methotrexate on radiologic progression in juvenile rheumatoid arthritis

AU - Harel, Liora

AU - Wagner‐Weiner, Linda

AU - Poznanski, Andrew K.

AU - Spencer, Charles H.

AU - Ekwo, Edem

AU - Magilavy, Daniel B.

PY - 1993/10

Y1 - 1993/10

N2 - Objective. To assess the effects of methotrexate (MTX) therapy on radiologic progression in juvenile rheumatoid arthritis (JRA). Methods. We evaluated serial wrist radiographs for carpal length in 23 JRA patients with bilateral wrist involvement, before and during MTX treatment. These carpal length measurements were compared with established norms for carpal length in a healthy pediatric population. Results. Both clinical responders to MTX (17 of 23 patients) and nonresponders (6 of 23) had decreasing carpal length prior to initiation of the treatment. Eleven of the 17 clinical responders had improved carpal length after a mean of 2.5 years of MTX treatment. All 6 clinical nonresponders had progressive loss of carpal length. Conclusion. MTX treatment resulted in radiologic improvement, as measured by carpal length, in the majority of children with JRA who had a clinical response to MTX.

AB - Objective. To assess the effects of methotrexate (MTX) therapy on radiologic progression in juvenile rheumatoid arthritis (JRA). Methods. We evaluated serial wrist radiographs for carpal length in 23 JRA patients with bilateral wrist involvement, before and during MTX treatment. These carpal length measurements were compared with established norms for carpal length in a healthy pediatric population. Results. Both clinical responders to MTX (17 of 23 patients) and nonresponders (6 of 23) had decreasing carpal length prior to initiation of the treatment. Eleven of the 17 clinical responders had improved carpal length after a mean of 2.5 years of MTX treatment. All 6 clinical nonresponders had progressive loss of carpal length. Conclusion. MTX treatment resulted in radiologic improvement, as measured by carpal length, in the majority of children with JRA who had a clinical response to MTX.

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Effects of methotrexate on radiologic progression in juvenile rheumatoid arthritis

Abstract

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