The effect of lithium on the membrane-bound Mg++-dependent ATPase of an adrenergic clone of mouse neuroblastoma was examined. Growing the neuroblastoma cells in the presence of lithium (2.5 mEq/L) did not affect the activity, pH optimum or temperature sensitivity of the enzyme. In vitro addition of lithium to cell membrane preparations likewise did not alter enzyme activity. While lithium has been shown to affect several Mg++-dependent enzymes, it has no apparent effect on the Mg++-dependent ATPase of mouse neuroblastoma.
|Number of pages||8|
|Journal||Communications In Psychopharmacology|
|State||Published - 1978|