Effects of lithium on the membrane-bound magnesium-dependent ATPase of mouse neuroblastoma cells

L. Shenkman, L. J. Traficante, J. Rotrosen, S. Gershon

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of lithium on the membrane-bound Mg++-dependent ATPase of an adrenergic clone of mouse neuroblastoma was examined. Growing the neuroblastoma cells in the presence of lithium (2.5 mEq/L) did not affect the activity, pH optimum or temperature sensitivity of the enzyme. In vitro addition of lithium to cell membrane preparations likewise did not alter enzyme activity. While lithium has been shown to affect several Mg++-dependent enzymes, it has no apparent effect on the Mg++-dependent ATPase of mouse neuroblastoma.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalCommunications In Psychopharmacology
Volume2
Issue number1
StatePublished - 1978
Externally publishedYes

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