Effects of indomethacin on plasma homovanillic acid concentration in normal subjects: a study of prostaglandin-dopamine interactions

René S. Kahn, Michael Davidson, Philip Kanof, Robert T. McQueeney, Rajkumar R. Singh, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review

Abstract

In laboratory animals, prostaglandins have been shown to act as endogenous neuromodulators of central dopamine (DA) activity. To examine the interaction between prostaglandins and DA in man, the effect of a prostaglandin synthesis inhibitor, indomethacin, was studied on plasma concentrations of the DA metabolite, homovanillic acid (pHVA). Indomethacin (150 mg PO) as compared to placebo significantly elevated mean pHVA concentrations in eight normal subjects. Results of this study support the hypothesis that, as in animals, inhibition of prostaglandin synthesis increases central DA turnover in man.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalPsychopharmacology
Volume103
Issue number1
DOIs
StatePublished - Jan 1991
Externally publishedYes

Keywords

  • Dopamine
  • Homovanillic acid
  • Indomethacin
  • Prostaglandin
  • Schizophrenia

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