TY - JOUR
T1 - Effects of FPL-55712 or indomethacin on leukotriene-induced coronary constriction in the intact pig heart
AU - Boyd, Lillie M.
AU - Ezra, David
AU - Feuerstein, Giora
AU - Goldstein, Robert E.
N1 - Funding Information:
The authors are grateful for the technical assistance of Mr. John Czaja. This investigation was supported by Uniformed Services University of the Health Sciences Protocol No. RO8329. Dr. Boyd is the recipient of Postdoctoral Fellowship IF 34 GM08713-01 from the National Heart, Lung, and Blood Institute, Bethesda, MD, U.S.A.
PY - 1983/5/6
Y1 - 1983/5/6
N2 - Intracoronary leukotriene D4, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.
AB - Intracoronary leukotriene D4, 0.1-3.0 μg (0.2-6.0 nmol), produced dose-dependent decreases in coronary flow of anesthetized pigs. Pretreatment with intracoronary FPL-55712 (0.1, 0.3 and 1.0 mg) reduced coronary constriction due to 1.0 μg leukotriene D4 by up to 77%. FPL-55712 did not produce sustained alterations is coronary flow, left ventricular end-diastolic pressure, systemic arterial pressure, or heart rate. Indomethacin pretreatment (6 mg/kg i.v.) had no effect on leukotriene-induced coronary constriction. Inhibition produced by FPL-55712 may be useful in disease states involving leukotriene-mediated coronary constriction.
KW - Coronary constriction
KW - FPL-55712
KW - Indomethacin
KW - Leukotriene D
UR - http://www.scopus.com/inward/record.url?scp=0020584338&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(83)90512-5
DO - 10.1016/0014-2999(83)90512-5
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AN - SCOPUS:0020584338
SN - 0014-2999
VL - 89
SP - 307
EP - 311
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3-4
ER -
