Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: A randomized, double-blind crossover study

Pnina Green*, Jacob Fuchs, Nili Schoenfeld, Leonard Leibovici, Yoav Lurie, Yitzhak Beigel, Zvi Rotenberg, Rivka Mamet, Pierre Budowski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Effects of a daily fish-oil supplement on serum lipids, apolipoproteins, and some platelet functions and hemorheologic variables were examined in 27 hyperlipidemic subjects in a randomized, controlled, double-blind, crossover fashion with an identically encapsulated vegetable oil serving as the control treatment. Despite the habitual high linoleic acid intake of the study population, significant incorporation of n-3 (ω-3) fatty acids into the serum, platelet, and erythrocyte lipids was observed after the fish-oil supplement. Ingestion of fish oil resulted in a 40% decrease in the triglyceride concentration, a 12% increase in HDL cholesterol, and a significant decrease in plasma viscosity, whereas the vegetable-oil placebo had no significant effect. We conclude that a moderate intake of fish oil (15 g/d) is a feasible treatment for hypertriglyceridemia even in patients with a background of high linoleic acid intake and that it may have a beneficial effect on several cardiovascular risk factors.

Original languageEnglish
Pages (from-to)1118-1124
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume52
Issue number6
StatePublished - Dec 1990

Keywords

  • Apolipoproteins
  • Erythrocyte deformability
  • Fish oil
  • Hyperlipidemia
  • Plasma viscosity
  • Platelet functions
  • Serum lipids
  • n-3 PUFAs

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