Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: A randomized, double-blind crossover study

P. Green, J. Fuchs, N. Schoenfeld, L. Leibovici, Y. Lurie, Y. Beigel, Z. Rotenberg, R. Mamet, P. Budowski

Research output: Contribution to journalArticlepeer-review

Abstract

Effects of a daily fish-oil supplement on serum lipids, apolipoproteins, and some platelet functions and hemorheologic variables were examined in 27 hyperlipidemic subjects in a randomized, controlled, double-blind, crossover fashion with an identically encapsulated vegetable oil serving as the control treatment. Despite the habitual high linoleic acid intake of the study population, significant incorporation of n-3 (ω-3) fatty acids into the serum, platelet, and erythrocyte lipids was observed after the fish-oil supplement. Ingestion of fish oil resulted in a 40% decrease in the triglyceride concentration, a 12% increase in HDL cholesterol, and a significant decrease in plasma viscosity, whereas the vegetable-oil placebo had no significant effect. We conclude that a moderate intake of fish oil (15 g/d) is a feasible treatment for hypertriglyceridemia even in patients with a background of high linoleic acid intake and that it may have a beneficial effect on several cardiovascular risk factors.

Original languageEnglish
Pages (from-to)1118-1124
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume52
Issue number6
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • Apolipoproteins
  • Erythrocyte deformability
  • Fish oil
  • Hyperlipidemia
  • N-3 PUFAs
  • Plasma viscosity
  • Platelet functions
  • Serum lipids

Fingerprint

Dive into the research topics of 'Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: A randomized, double-blind crossover study'. Together they form a unique fingerprint.

Cite this