Effects of extracorporeal membrane oxygenation on morphine pharmacokinetics in infants

O. Dagan, J. Klein, D. Bohn, G. Koren

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To study the effect of extracorporeal membrane oxygenation (ECMO) on the pharmacokinetics of morphine in infants. Design: A prospective, comparative study of morphine pharmacokinetics during and after ECMO. Setting: The pediatric intensive care unit at a children's hospital. Patients: Seven infants, aged 1 day to 12 months, requiring ECMO. Intervention: Infusion of morphine. Measurement and Main Results: Steady- state concentrations of morphine were used to generate a morphine clearance rate. Plasma clearance rate of morphine increased from 0.574 ± 0.3 L/kg/hr to 1.058 ± 0.727 L/kg/hr after discontinuation of ECMO (p < .01). Two infants experienced a clinical picture consistent with opioid withdrawal. Conclusion: Infants requiring morphine after ECMO may require higher dose rates to maintain adequate sedation.

Original languageEnglish
Pages (from-to)1099-1101
Number of pages3
JournalCritical Care Medicine
Volume22
Issue number7
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • critical illness
  • drug metabolism
  • extracorporeal membrane oxygenation
  • infants
  • intensive care unit, pediatric
  • morphine
  • opiates
  • pharmacodynamics
  • pharmacokinetics
  • pharmacology
  • sedation

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