TY - JOUR
T1 - Effects of enteral nutrition on Crohn's Disease
T2 - Clues to the impact of diet on disease pathogenesis
AU - Levine, Arie
AU - Wine, Eytan
PY - 2013/5
Y1 - 2013/5
N2 - Crohn's disease is a complex inherited disorder of unknown pathogenesis with environmental, genetic, and microbial factors involved in the development of the disease. A remarkable feature of this disease, especially, but not limited to childhood, is the effective response to exclusive enteral nutrition therapy and the observed benefit from exclusion of normal diet (principle of exclusivity). We reviewed the possible mechanisms of action of enteral nutrition for induction of remission and provided a hypothetical model (herein termed bacterial penetration cycle) that integrates dietary components, bacteria, susceptibility genes, and the innate immune response in the pathogenesis of Crohn's disease.
AB - Crohn's disease is a complex inherited disorder of unknown pathogenesis with environmental, genetic, and microbial factors involved in the development of the disease. A remarkable feature of this disease, especially, but not limited to childhood, is the effective response to exclusive enteral nutrition therapy and the observed benefit from exclusion of normal diet (principle of exclusivity). We reviewed the possible mechanisms of action of enteral nutrition for induction of remission and provided a hypothetical model (herein termed bacterial penetration cycle) that integrates dietary components, bacteria, susceptibility genes, and the innate immune response in the pathogenesis of Crohn's disease.
KW - Child
KW - Crohn's disease
KW - Diet
KW - Environment
KW - Exclusive enteral nutrition
KW - Pathogenesis
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84879209004&partnerID=8YFLogxK
U2 - 10.1097/MIB.0b013e3182802acc
DO - 10.1097/MIB.0b013e3182802acc
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C2 - 23399738
AN - SCOPUS:84879209004
SN - 1078-0998
VL - 19
SP - 1322
EP - 1329
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
IS - 6
ER -