Effects of endotoxin-associated protein on hematopoiesis

R. Porat*, M. Yanoov, M. A. Johns, S. Shibolet, R. Michalevicz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Endotoxin-associated protein (EAP), a gram-negative bacterial cell wall component, was evaluated for its effects on hematopoietic colony formation in vitro. Colony-stimulating activity, induced by EAP on circulating and bone marrow progenitor cells, was found to be partially mediated by T cells and augmented by interleukin-3. The addition of anti-human interleukin-1 (IL-1) antibodies reduced EAP activity, suggesting that EAP may induce IL-1 production. However, EAP was shown to promote the growth of mature progenitor cells independently, unlike the effects of IL-1 on the hematopoietic system. These studies demonstrate that bacterial components other than lipopolysaccharide, such as EAP, may have hematopoietic activity.

Original languageEnglish
Pages (from-to)1756-1760
Number of pages5
JournalInfection and Immunity
Volume60
Issue number5
StatePublished - 1992
Externally publishedYes

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