TY - JOUR
T1 - Effects of disopyramide on reperfusion arrhythmias in dogs
AU - Chagnac, A.
AU - Pelleg, A.
AU - Belhassen, B.
AU - Lubliner, J.
AU - Vidné, B.
AU - Laniado, S.
PY - 1982
Y1 - 1982
N2 - We tested the effect of disopyramide on reperfusion arrhythmias in mongrel dogs. The control group consisted of 27 dogs. Twenty-nine dogs received two intravenous doses of disopyramide (total: 5.3 mg/kg) before and during the occlusion of the left anterior descending coronary artery. The blood levels of disopyramide averaged 3.95 ± 0.95 μg/ml and 5.9 ± 1.1 μg/ml, 2.5 and 9.5 min after the ligation. The incidence of reperfusion arrhythmias was significantly (p < 0.05) lower in the treated group (7.5%) than in the control group (33.3%). Disopyramide also lowered the incidence of arrhythmias during the occlusion period (14% vs. 52%, p < 0.01). Both groups showed a correlation between the incidence of arrhythmias during the occlusion period and on reperfusion.
AB - We tested the effect of disopyramide on reperfusion arrhythmias in mongrel dogs. The control group consisted of 27 dogs. Twenty-nine dogs received two intravenous doses of disopyramide (total: 5.3 mg/kg) before and during the occlusion of the left anterior descending coronary artery. The blood levels of disopyramide averaged 3.95 ± 0.95 μg/ml and 5.9 ± 1.1 μg/ml, 2.5 and 9.5 min after the ligation. The incidence of reperfusion arrhythmias was significantly (p < 0.05) lower in the treated group (7.5%) than in the control group (33.3%). Disopyramide also lowered the incidence of arrhythmias during the occlusion period (14% vs. 52%, p < 0.01). Both groups showed a correlation between the incidence of arrhythmias during the occlusion period and on reperfusion.
KW - Coronary artery occlusion
KW - Disopyramide
KW - Reperfusion arrhythmias
KW - Ventricular fibrillation
UR - http://www.scopus.com/inward/record.url?scp=0020396605&partnerID=8YFLogxK
U2 - 10.1097/00005344-198211000-00018
DO - 10.1097/00005344-198211000-00018
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AN - SCOPUS:0020396605
SN - 0160-2446
VL - 4
SP - 994
EP - 998
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
IS - 6
ER -
