Effects of D- and DL-Propranolol on Myocardial Adenyl Cyclase Activity

Babeth Rabinowitz; William W. Parmley; George Bonnoris

doi:10.3181/00379727-143-37473

Effects of D- and DL-Propranolol on Myocardial Adenyl Cyclase Activity

Babeth Rabinowitz^*
, William W. Parmley
, George Bonnoris

^*Corresponding author for this work

Cedars-Sinai Medical Center

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The direct effects of d- and dl-propranolol (Inderal) on myocardial adenyl cyclase activity were determined on in vitro preparations from cats and guinea pigs. In both species, dl-propranolol depressed myocardial adenyl cyclase activity at all dose levels greater than 10^-8M. The pure dextroisomer produced less depression of the adenyl cyclase activity. In preparations from reserpinized cats, d-propranolol had no effect on myocardial adenyl cyclase activity up to 10-⁴M, while the effects of dl-propranolol were slightly reduced. Since d- and dl-propranolol have identical depressive effects on myocardial contractile force, the present data demonstrate a dissociation between their effects on adenyl cyclase activity and force development.

Original language	English
Pages (from-to)	1072-1076
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume	143
Issue number	4
DOIs	https://doi.org/10.3181/00379727-143-37473
State	Published - Sep 1973
Externally published	Yes

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title = "Effects of D- and DL-Propranolol on Myocardial Adenyl Cyclase Activity",

abstract = "The direct effects of d- and dl-propranolol (Inderal) on myocardial adenyl cyclase activity were determined on in vitro preparations from cats and guinea pigs. In both species, dl-propranolol depressed myocardial adenyl cyclase activity at all dose levels greater than 10-8M. The pure dextroisomer produced less depression of the adenyl cyclase activity. In preparations from reserpinized cats, d-propranolol had no effect on myocardial adenyl cyclase activity up to 10-4M, while the effects of dl-propranolol were slightly reduced. Since d- and dl-propranolol have identical depressive effects on myocardial contractile force, the present data demonstrate a dissociation between their effects on adenyl cyclase activity and force development.",

author = "Babeth Rabinowitz and Parmley, \{William W.\} and George Bonnoris",

year = "1973",

month = sep,

doi = "10.3181/00379727-143-37473",

language = "אנגלית",

volume = "143",

pages = "1072--1076",

journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",

issn = "0037-9727",

publisher = "Society for Experimental Biology and Medicine",

number = "4",

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Effects of D- and DL-Propranolol on Myocardial Adenyl Cyclase Activity. / Rabinowitz, Babeth; Parmley, William W.; Bonnoris, George.
In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.), Vol. 143, No. 4, 09.1973, p. 1072-1076.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of D- and DL-Propranolol on Myocardial Adenyl Cyclase Activity

AU - Rabinowitz, Babeth

AU - Parmley, William W.

AU - Bonnoris, George

PY - 1973/9

Y1 - 1973/9

N2 - The direct effects of d- and dl-propranolol (Inderal) on myocardial adenyl cyclase activity were determined on in vitro preparations from cats and guinea pigs. In both species, dl-propranolol depressed myocardial adenyl cyclase activity at all dose levels greater than 10-8M. The pure dextroisomer produced less depression of the adenyl cyclase activity. In preparations from reserpinized cats, d-propranolol had no effect on myocardial adenyl cyclase activity up to 10-4M, while the effects of dl-propranolol were slightly reduced. Since d- and dl-propranolol have identical depressive effects on myocardial contractile force, the present data demonstrate a dissociation between their effects on adenyl cyclase activity and force development.

AB - The direct effects of d- and dl-propranolol (Inderal) on myocardial adenyl cyclase activity were determined on in vitro preparations from cats and guinea pigs. In both species, dl-propranolol depressed myocardial adenyl cyclase activity at all dose levels greater than 10-8M. The pure dextroisomer produced less depression of the adenyl cyclase activity. In preparations from reserpinized cats, d-propranolol had no effect on myocardial adenyl cyclase activity up to 10-4M, while the effects of dl-propranolol were slightly reduced. Since d- and dl-propranolol have identical depressive effects on myocardial contractile force, the present data demonstrate a dissociation between their effects on adenyl cyclase activity and force development.

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JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

IS - 4

ER -

Effects of D- and DL-Propranolol on Myocardial Adenyl Cyclase Activity

Abstract

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