TY - JOUR
T1 - Effects of cannabidiol in males and females in two different rat models of depression
AU - Shbiro, Liat
AU - Hen-Shoval, Danielle
AU - Hazut, Noa
AU - Rapps, Kayla
AU - Dar, Shira
AU - Zalsman, Gil
AU - Mechoulam, Raphael
AU - Weller, Aron
AU - Shoval, Gal
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/3/15
Y1 - 2019/3/15
N2 - The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.
AB - The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.
KW - Animal models of depression
KW - Cannabidiol
KW - Depression
KW - Flinders Sensitive Line
KW - Wistar- Kyoto rats
UR - http://www.scopus.com/inward/record.url?scp=85058631072&partnerID=8YFLogxK
U2 - 10.1016/j.physbeh.2018.12.019
DO - 10.1016/j.physbeh.2018.12.019
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C2 - 30571957
AN - SCOPUS:85058631072
SN - 0031-9384
VL - 201
SP - 59
EP - 63
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -