TY - JOUR
T1 - Effects of amygdaloid kindling on the pain threshold of the rat
AU - Frenk, Hanan
AU - Yitzhaky, Jacob
N1 - Funding Information:
1 This research was made possible by agrant to H.F. from the Israel Center for Psychobiology, the Charles E. Smith Family Foundation. Naloxone was generously provided by Endo Laboratories, Garden City, New York. This work is part of a doctoral dissertation to be submitted by J.Y. to Tel-Aviv University.
PY - 1981/3
Y1 - 1981/3
N2 - The amygdaloid complex in male Wistar rats was electrically stimulated in the kindling paradigm and tail-flick tests were carried out to measure the pain threshold before and after each daily stimulation. Amygdaloid kindling was found to produce a gradual elevation of the pain threshold with time, which reached its peak after about 6 days and disappeared before behavioral convulsions occurred. This elevation of the pain threshold was attenuated in naloxone (5 mg/kg)-pretreated and morphine-tolerant rats, and was not observed in sham-kindled controls. These results support the hypothesis that endogenous opioids are secreted as a result of amygdaloid stimulation.
AB - The amygdaloid complex in male Wistar rats was electrically stimulated in the kindling paradigm and tail-flick tests were carried out to measure the pain threshold before and after each daily stimulation. Amygdaloid kindling was found to produce a gradual elevation of the pain threshold with time, which reached its peak after about 6 days and disappeared before behavioral convulsions occurred. This elevation of the pain threshold was attenuated in naloxone (5 mg/kg)-pretreated and morphine-tolerant rats, and was not observed in sham-kindled controls. These results support the hypothesis that endogenous opioids are secreted as a result of amygdaloid stimulation.
UR - http://www.scopus.com/inward/record.url?scp=0019456014&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(81)90026-1
DO - 10.1016/0014-4886(81)90026-1
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AN - SCOPUS:0019456014
SN - 0014-4886
VL - 71
SP - 487
EP - 496
JO - Experimental Neurology
JF - Experimental Neurology
IS - 3
ER -