Effects of amygdaloid kindling on the pain threshold of the rat

Hanan Frenk, Jacob Yitzhaky

Research output: Contribution to journalArticlepeer-review


The amygdaloid complex in male Wistar rats was electrically stimulated in the kindling paradigm and tail-flick tests were carried out to measure the pain threshold before and after each daily stimulation. Amygdaloid kindling was found to produce a gradual elevation of the pain threshold with time, which reached its peak after about 6 days and disappeared before behavioral convulsions occurred. This elevation of the pain threshold was attenuated in naloxone (5 mg/kg)-pretreated and morphine-tolerant rats, and was not observed in sham-kindled controls. These results support the hypothesis that endogenous opioids are secreted as a result of amygdaloid stimulation.

Original languageEnglish
Pages (from-to)487-496
Number of pages10
JournalExperimental Neurology
Issue number3
StatePublished - Mar 1981


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