Effects of alprazolam on increases in hormonal and anxiety levels induced by meta-chlorophenylpiperazine

Serge Sevy, Serena Lynn Brown*, Scott Wetzler, Moshe Kotler, Avi Molcho, Robert Plutchik, Herman M. van Praag

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effects of alprazolam, a triazolobenzodiazepine, on hormonal and behavioral responses induced by meta-chlorophenylpiperazine (MCPP), a serotonin receptor agonist, were investigated in 10 healthy men. Alprazolam (0.5 mg) or placebo was given 1 hour before MCPP (0.5 mg/kg) or placebo. Cortisol, prolactin, and growth hormone (GH) release, MCPP and alprazolam plasma levels, anxiety level, and panic symptoms were measured over 210 minutes. MCPP was found to increase cortisol, prolactin, GH, and anxiety levels. Alprazolam decreased cortisol and GH levels but had no effect on prolactin. When used in combination with MCPP, alprazolam blunted MCPP-induced cortisol and GH release, and it blocked the anxiogenic effects of MCPP.

Original languageEnglish
Pages (from-to)219-229
Number of pages11
JournalPsychiatry Research
Issue number3
StatePublished - Sep 1994
Externally publishedYes


  • Serotonin
  • cortisol
  • growth hormone
  • prolactin


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