EFFECTS OF ACUTE COCAINE TREATMENT ON THE TURNOVER OF 5‐HYDROXYTRYPTAMINE IN THE RAT BRAIN

E. FRIEDMAN, S. GERSHON, J. ROTROSEN

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of cocaine (20 mg/kg s.c.) on 5‐hydroxytryptamine (5‐HT) turnover were examined in rats. In vivo cocaine administration resulted in decreased turnover of 5‐HT, as indicated by the decreased accumulation of 5‐HT after pargyline administration and the decreased accumulation of 5‐hydroxyindoleacetic acid (5‐HIAA) following probenecid injection. A time‐related decrease in 5‐HIAA concentrations and a small fall in 5‐HT concentrations in the whole brain were observed following the acute administration of cocaine hydrochloride (20 mg/kg). Tryptophan levels were found to be slightly decreased in the brain. Enhanced reactivity, but neither stereotypy nor hyperthermia, was observed following cocaine injection (20 mg/kg). It is concluded that cocaine inhibits the turnover of brain 5‐HT and that this action of cocaine may be responsible for the differences in a number of pharmacological effects between cocaine and amphetamine. 1975 British Pharmacological Society

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalBritish Journal of Pharmacology
Volume54
Issue number1
DOIs
StatePublished - May 1975
Externally publishedYes

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