Effectiveness of single- vs dual-coil implantable defibrillator leads: An observational analysis from the SIMPLE study

Jörg Neuzner, Stefan H. Hohnloser, Valentina Kutyifa, Michael Glikson, Thomas Dietze, Philippe Mabo, Xavier Vinolas, Josef Kautzner, Gilles O'Hara, Thomas Lawo, Johannes Brachmann, Liselot VanErven, Fredrik Gadler, Ursula Appl, Jia Wang, Stuart J. Connolly, Jeff S. Healey

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Dual-coil leads (DC-leads) were the standard of choice since the first nonthoracotomy implantable cardioverter/defibrillator (ICD). We used contemporary data to determine if DC-leads offer any advantage over single-coil leads (SC-leads), in terms of defibrillation efficacy, safety, clinical outcome, and complication rates. Methods and Results: In the Shockless IMPLant Evaluation study, 2500 patients received a first implanted ICD and were randomized to implantation with or without defibrillation testing. Two thousand and four hundred seventy-five patients received SC-coil or DC-coil leads (SC-leads in 1025/2475 patients; 41.4%). In patients who underwent defibrillation testing (n = 1204), patients with both lead types were equally likely to achieve an adequate defibrillation safety margin (88.8% vs 91.2%; P = 0.16). There was no overall effect of lead type on the primary study endpoint of “failed appropriate shock or arrhythmic death” (adjusted HR 1.18; 95% CI, 0.86-1.62; P = 0.300), and on all-cause mortality (SC-leads: 5.34%/year; DC-leads: 5.48%/year; adjusted HR 1.16; 95% CI, 0.94-1.43; P = 0.168). However, among patients without prior heart failure (HF), and SC-leads had a significantly higher risk of failed appropriate shock or arrhythmic death (adjusted HR 7.02; 95% CI, 2.41-20.5). There were no differences in complication rates. Conclusion: In this nonrandomized evaluation, there was no overall difference in defibrillation efficacy, safety, outcome, and complication rates between SC-leads and DC-leads. However, DC-leads were associated with a reduction in the composite of failed appropriate shock or arrhythmic death in the subgroup of non-HF patients. Considering riskier future lead extraction with DC-leads, SC-leads appears to be preferable in the majority of patients.

Original languageEnglish
Pages (from-to)1078-1085
Number of pages8
JournalJournal of Cardiovascular Electrophysiology
Volume30
Issue number7
DOIs
StatePublished - Jul 2019
Externally publishedYes

Keywords

  • all-cause mortality
  • arrhythmic death
  • defibrillation shock efficacy
  • failed appropriate shocks
  • implantable cardioverter-defibrillator
  • intraoperative defibrillation testing
  • single-coil and dual-coil leads

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