Effectiveness of rotavirus vaccines for prevention of rotavirus gastroenteritis-associated hospitalizations in Israel: A case-control study

Khitam Muhsen, Lester Shulman, Eias Kasem, Uri Rubinstein, Jacob Shachter, Adi Kremer, Sophy Goren, Ilana Zilberstein, Gabby Chodick, Moshe Ephros, Dani Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

The association between rotavirus gastroenteritis (RVGE)-associated hospitalization and rotavirus vaccine receipt was examined, and vaccine effectiveness was estimated in a case-control study conducted between 11/2007 and 12/2009 among Israeli children age eligible for rotavirus vaccination. Cases (n = 111) were hospitalized children with diarrhea testing positive for rotavirus by immunochromatography. Controls (n = 216) were hospitalized children with diarrhea testing negative for rotavirus. Among controls 36 (16.7%) children were vaccinated against rotavirus compared with two children (1.8%) among cases (p < 0.001). Rotavirus immunization was associated with lower risk of RVGE-associated hospitalization; adjusted OR 0.106 (95% CI 0.024, 0.481), yielding a vaccine effectiveness of 89.4% (95% CI 51.9%, 97.6%) in preventing hospitalization. These data demonstrate high effectiveness of rotavirus vaccines in a high income country.

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalHuman Vaccines
Volume6
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • Acute gastroenteritis
  • Case-control study
  • Children
  • Effectiveness
  • Hospitalizations
  • Israel
  • Rotavirus vaccines

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