Effective negative pressure wound therapy for open wounds: The importance of consistent pressure delivery

Aleksei Orlov, Amit Gefen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Two distinct design concepts exist for single-use negative pressure wound therapy systems: Canister-based versus canisterless. The canister-based technology provides intrinsic stable delivery of the intended negative pressure, because exudate is constantly transferred from the wound into a canister, thereby preventing dressing saturation. In contrast, with a canisterless system, where delivery of the negative pressure depends on continuous evaporation of wound fluids from its dressing, loss of the intended wound-bed pressure may occur due to dressing saturation. To investigate whether these two designs differ in their mechanobiological effect with respect to magnitudes and distributions of tissue strain fields under the absorptive dressing, termed the influence zone, we integrated computational modelling with an animal study. This influence zone must be of biologically influential strain levels and extend sufficiently into the peri-wound for stimulating fibroblasts to migrate and progress the healing. We found that an effective influence zone requires continuous delivery of the intended pressure to the wound-bed. Loss of negative pressure at the wound-bed below 40 mmHg adversely lowered the peri-wound stimulation around a 120 × 70 mm sized wound to less than one-third of the baseline stimulation, and further pressure decreases to 20 mmHg or lower resulted in complete lack of peri-wound mechano-stimulation.

Original languageEnglish
Pages (from-to)328-344
Number of pages17
JournalInternational Wound Journal
Issue number2
StatePublished - Feb 2023


FundersFunder number
Mölnlycke Health Care
H2020 Marie Skłodowska-Curie Actions
Ministry of Science and Technology, Israel3‐17421
Horizon 2020811965


    • animal study
    • bioengineering laboratory research of chronic wounds
    • diabetic foot ulcer
    • finite element modelling
    • pressure ulcer/injury


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