TY - JOUR
T1 - Effect of zinc and rare-earth element addition on mechanical, corrosion, and biological properties of magnesium
AU - Kottuparambil, Rakesh Rajan
AU - Bontha, Srikanth
AU - Rangarasaiah, Ramesh Motagondanahalli
AU - Arya, Shashi Bhushan
AU - Jana, Anuradha
AU - Das, Mitun
AU - Balla, Vamsi Krishna
AU - Amrithalingam, Srinivasan
AU - Prabhu, T. Ram
N1 - Publisher Copyright:
© 2018 Materials Research Society.
PY - 2018/10/29
Y1 - 2018/10/29
N2 - The present work aims to understand the effect of zinc and rare-earth element addition (i.e., 2 wt% Gd, 2 wt% Dy, and 2 wt% of Gd and Nd individually) on the microstructure evolution, mechanical properties, in vitro corrosion behavior, and cytotoxicity of Mg for biomedical application. The microstructure results indicate that the Mg-Zn-Gd alloy consists of the lamellar long period stacking ordered phase. The electrochemical and immersion corrosion behavior were studied in Hanks balanced salt solution. Enhanced corrosion resistance with reduced hydrogen evolution volume and magnesium (Mg2+) ion release were estimated for the Mg-Zn-Gd alloy as compared to the other two alloy systems. At the early stage of corrosion, formation of the oxide film inhibited the corrosion propagation. However, at the later stages, the breaking of the oxide film leads to shallow pitting mode of corrosion. The ultimate tensile strength of Mg-Zn-Gd-Nd is better than the other two alloys due to the uniform distribution of the Mg12Nd precipitate phase. The moderate strength in the Mg-Zn-Gd alloy is due to the low volume fraction of the secondary phase. The MTT (methylthiazoldiphenyl-tetrazolium bromide) assay study was carried out to understand the cell cytotoxicity on the alloy surfaces. Studies revealed that all three alloys had significant cellular adherence and no adverse effect on cells.
AB - The present work aims to understand the effect of zinc and rare-earth element addition (i.e., 2 wt% Gd, 2 wt% Dy, and 2 wt% of Gd and Nd individually) on the microstructure evolution, mechanical properties, in vitro corrosion behavior, and cytotoxicity of Mg for biomedical application. The microstructure results indicate that the Mg-Zn-Gd alloy consists of the lamellar long period stacking ordered phase. The electrochemical and immersion corrosion behavior were studied in Hanks balanced salt solution. Enhanced corrosion resistance with reduced hydrogen evolution volume and magnesium (Mg2+) ion release were estimated for the Mg-Zn-Gd alloy as compared to the other two alloy systems. At the early stage of corrosion, formation of the oxide film inhibited the corrosion propagation. However, at the later stages, the breaking of the oxide film leads to shallow pitting mode of corrosion. The ultimate tensile strength of Mg-Zn-Gd-Nd is better than the other two alloys due to the uniform distribution of the Mg12Nd precipitate phase. The moderate strength in the Mg-Zn-Gd alloy is due to the low volume fraction of the secondary phase. The MTT (methylthiazoldiphenyl-tetrazolium bromide) assay study was carried out to understand the cell cytotoxicity on the alloy surfaces. Studies revealed that all three alloys had significant cellular adherence and no adverse effect on cells.
KW - In vitro degradation
KW - Mg-Zn-REE alloy
KW - mechanical properties
UR - http://www.scopus.com/inward/record.url?scp=85054143877&partnerID=8YFLogxK
U2 - 10.1557/jmr.2018.311
DO - 10.1557/jmr.2018.311
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AN - SCOPUS:85054143877
SN - 0884-2914
VL - 33
SP - 3466
EP - 3478
JO - Journal of Materials Research
JF - Journal of Materials Research
IS - 20
ER -