Effect of vitamin D analogues on acute cardiorenal syndrome: A laboratory rat model

Ofer Havakuk, Michal Entin-Meer, Jeremy Ben-Shoshan, Pavel Goryainov, Sofia Maysel-Auslender, Erel Joffe, Gad Keren*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Vitamin D has been shown to induce beneficial effects on cardiovascular and renal morbidity by regulating inflammation and tissue fibrosis. objectives: To evaluate the effect of vitamin D analogues on cardiac function and fibrosis in an animal model of cardiorenal syndrome. Methods: Unilateral nephrectomy was performed and myocardial infarction induced in rats. The rats were treated with vitamin D receptor activator (VDRA, paricalcitol, 40 ng/250 g x 3/week) versus a vehicle. A third group of animals, which served as the control, underwent sham surgery and received no treatment. After 4 weeks of treatment, cardiac function and fibrosis were assessed by trans-thoracic echo and histology, respectively. As a parameter of systemic inflammation, previously shown to be altered in acute coronary syndrome, T regulatory (Treg) cell levels were measured by flow cytometry. Renal dysfunction was documented by standard laboratory tests. results: After 4 weeks of treatment, no significant improvement in cardiac function parameters was noted following VDRA administration. VDRA treatment did not significantly alter Treg cell systemic levels. Consistently, despite a trend toward less extent of myocardial fibrosis, we found no clear beneficial effects of VDRA on myocardial tissue inflammation and remodeling. conclusions: Vitamin D treatment showed no beneficial effects on cardiac function parameters and fibrosis in an animal model of cardiorenal syndrome.

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalIsrael Medical Association Journal
Volume15
Issue number11
StatePublished - Nov 2013

Keywords

  • Cardiac function
  • Cardiorenal syndrome (CRS)
  • Myocardial fibrosis
  • T regulatory cells (Treg)
  • Vitamin D analogues

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