Effect of verapamil on platelet surface ultrastructure and calcium content

M. Djaldetti, R. Gilgal, P. Fishman, I. Zahavi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of verapamil on the surface ultrastructure and calcium content of human platelets was studied by scanning electron microscopy and X-ray microanalysis. The results showed that the drug prevents platelet pseudopodia formation and causes a dose-dependent inhibition of platelet calcium concentration. The significance of these findings in the explanation of the inhibitory effect of verapamil on platelet aggregation is discussed.

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalActa Haematologica
Volume79
Issue number1
DOIs
StatePublished - 1988

Keywords

  • Platelet calcium content
  • Scanning electron microscopy
  • Verapamil
  • X-ray microanalysis

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