Effect of total lymphoid irradiation (TLI) on the primary and secondary antibody response to sheep red blood cells

Israel Zan-Bar, Shimon Slavin, Samuel Strober

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of total lymphoid irradiation (TLI) on the primary and secondary hemagglutinin response to sheep red blood cells (SRBC) was studied in BALB/c mice. The primary response was eliminated for 1 month and began to return by Day 44. The latter response was IgM, and the IgG response did not return until approximately 200 days after TLI. The prolonged immunosuppression required inclusion of the thymus in the radiation field. Mice treated with single-dose whole-body irradiation (WBI) regained a normal IgG response within 28 days after irradiation. Immunization of mice prior to treatment with TLI or WBI resulted in a vigorous IgG response when mice were boosted 1 month after irradiation.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalCellular Immunology
Volume45
Issue number1
DOIs
StatePublished - Jun 1979
Externally publishedYes

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