Effect of three days starvation on the phagocytic activity of rat peritoneal macrophages

Hertzel Salman, Michael Bergman, Hanna Bessler, Svetlana Alexandrova, Rachel Straussberg, Izhar Zahavi, Meir Djalditte

Research output: Contribution to journalArticlepeer-review

Abstract

To examine the effect of starvation on the phagocytic activity of rat peritoneal macrophages, 8 animals were kept for 3 days on water supply only. The cells showed an increased capacity for superoxide anion production and a marked decrease in their ability to engulf latex particles. The corticosterone level of the fasting animals was markedly increased, an observation suggesting that the alteration of macrophage function could be hormonally mediated. The findings in the present study indicate that the decreased phagocytic capacity of peritoneal macrophages following starvation may be one of the factors responsible for the increased susceptibility to infections in malnourished individuals.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalActa Haematologica
Volume100
Issue number1
DOIs
StatePublished - 1998

Keywords

  • Corticosterone
  • Peritoneal macrophages, rat
  • Phagocytosis
  • Starvation
  • Superoxide anions

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