Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy

Liffert Vogt, Carlos Chiurchiu, Harbajan Chadha-Boreham, Parisa Danaietash, Jasper Dingemanse, Samy Hadjadj, Henry Krum, Gerjan Navis, Eric Neuhart, Aneliya I. Parvanova, Piero Ruggenenti, Arend Jan Woittiez, Reuven Zimlichman, Giuseppe Remuzzi, Dick De Zeeuw

Research output: Contribution to journalArticlepeer-review

Abstract

The urotensin system has been hypothesized to play an important role in the pathophysiology of diabetic nephropathy. In this multicenter, randomized, double-blind, placebo-controlled, 2-period crossover study, the effects of the urotensin receptor antagonist palosuran on urinary albumin excretion and blood pressure in hypertensive patients with type 2 diabetic nephropathy treated with a single blocker of the renin-angiotensin-aldosterone system were assessed. Patients with 24-hour albuminuria >0.5 and <3.0 g, systolic blood pressure >135 and <170 mm Hg, and/or diastolic blood pressure >85 and <110 mm Hg received both palosuran 125 mg BID and placebo for 4 weeks each. Fifty-four patients (20% women; mean age: 61.6 years, blood pressure: 155/84 mm Hg, and albuminuria: 1016 mg per 24 hours) were included in the per-protocol analysis. Palosuran did not affect albuminuria, blood pressure, glomerular filtration rate, or renal plasma flow significantly. These results question whether urotensin receptor antagonism represents a new treatment strategy in this high-risk patient population.

Original languageEnglish
Pages (from-to)1206-1209
Number of pages4
JournalHypertension
Volume55
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Albuminuria
  • Diabetic nephropathy
  • Hypertension
  • Palosuran
  • RAAS blockade
  • Urotensin antagonist

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