Effect of the inhibitory material from male genital tract on natural killing activities

Z. H. Marcus, F. Dondero, B. Lunenfeld, L. M. Lewin

Research output: Contribution to journalArticlepeer-review

Abstract

A male inhibitory material (HuSePl-Frl) was separated from normal human seminal plasma by gel filtration on Sephadex G-100. This material has high avidity for cell membranes of human red blood cells (RBC). In vitro, PHA-M-induced blast transformation of human lymphocytes is inhibited by small quantities of HuSePl-Frl. This inhibition was also evident when RBC coated with HuSePl-Frl is added to mitogen stimulated lymphocytes in cultures. Small quantities of HuSePl-Frl are inhibitory to natural killer (NK) cell activation. The modulating role of the HuSePl-Frl in preventing the spermatozoal rejection during fertilization is discussed.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalImmunology Letters
Volume10
Issue number1
DOIs
StatePublished - 1985

Keywords

  • male genital tract inhibitory material - natural killer activity

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