Effect of the combination of cisplatinum and radiation in the rabbit's brain

Juana Schiffer*, Natalio Walach, Gili Lushkov, Abraham Nyska, Ruth Gur, Lea Pollak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of cisplatinum as a potential radiosensitizer in brain tumors is controversial. We examined the effect of the combination of cisplatinum with radiation compared to radiation alone in rabbits' brain. All rabbits were irradiated and cisplatinum was injected intravenously into part of them. Therapeutic doses of cisplatinum and irradiation were given. The rabbits were euthanised at different intervals according to protocol. The general clinical and neurological condition of the rabbits was unaffected, and histopathological examination of the rabbit's brain was normal. The purpose of this study was to establish the effect of cisplatinum followed by cranial irradiation in therapeutic doses to the normal rabbit's brain.

Original languageEnglish
Pages (from-to)454-456
Number of pages3
JournalNeurological Research
Issue number5
StatePublished - Oct 1996


  • Intravenous treatment
  • brain irradiation
  • cisplatinum
  • drug effect on brain


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