Effect of the combination of cisplatinum and radiation in the rabbit's brain

Juana Schiffer, Natalio Walach, Gili Lushkov, Abraham Nyska, Ruth Gur, Lea Pollak

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of cisplatinum as a potential radiosensitizer in brain tumors is controversial. We examined the effect of the combination of cisplatinum with radiation compared to radiation alone in rabbits' brain. All rabbits were irradiated and cisplatinum was injected intravenously into part of them. Therapeutic doses of cisplatinum and irradiation were given. The rabbits were euthanised at different intervals according to protocol. The general clinical and neurological condition of the rabbits was unaffected, and histopathological examination of the rabbit's brain was normal. The purpose of this study was to establish the effect of cisplatinum followed by cranial irradiation in therapeutic doses to the normal rabbit's brain.

Original languageEnglish
Pages (from-to)454-456
Number of pages3
JournalNeurological Research
Volume18
Issue number5
DOIs
StatePublished - Oct 1996

Keywords

  • Intravenous treatment
  • brain irradiation
  • cisplatinum
  • drug effect on brain

Fingerprint

Dive into the research topics of 'Effect of the combination of cisplatinum and radiation in the rabbit's brain'. Together they form a unique fingerprint.

Cite this