Effect of the adhesive antibiotic TA on adhesion and initial growth of E. coli on silicone rubber

Eliahu Simhi, Henry C. Van Der Mei, Eliora Z. Ron, Eugene Rosenberg, Henk J. Busscher

Research output: Contribution to journalArticlepeer-review

Abstract

Catheter-associated urinary tract infection is the most common nosocomial infection, and contributes to patient morbidity and mortality. We investigated the effect that the TA adhesive antibiotic had on adhesion and initial growth in urine of Escherichia coli on silicone rubber. The TA antibiotic had reduced adhesion, and inhibited initial growth of the bacteria on the surface. Since adhesion and initial growth on the surface are an essential part of biofilm formation and subsequent infection, we speculate that the TA antibiotic coating might decrease the infection rate associated with indwelling urinary catheter. Copyright (C) 2000 Federation of European Microbiological Societies.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalFEMS Microbiology Letters
Volume192
Issue number1
DOIs
StatePublished - 1 Nov 2000

Keywords

  • Bacterial adhesion
  • Biofilm
  • Escherichia coli
  • Urinary tract infection

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