Effect of Systemic Hypertension With Versus Without Left Ventricular Hypertrophy on the Progression of Atrial Fibrillation (from the Euro Heart Survey)

Ömer Erküner, Elton A.M.P. Dudink, Robby Nieuwlaat, Michiel Rienstra, Isabelle C. Van Gelder, A. John Camm, Alessandro Capucci, Günter Breithardt, Jean Yves LeHeuzey, Gregory Y.H. Lip, Harry J.G.M. Crijns, Justin G.L.M. Luermans, Dieter Andresen, Wynn Davies, Samuel Le´vy, Bertil Olsson, Etienne Aliot, Stuart Cobbe, Massimo Santini, Panos VardasMalika Manini, Claire Bramley, Vale´rie Laforest, Charles Taylor, Susan Del Gaiso, Kurt Huber, Guy De Backer, Vera Sirakova, Roman Cerbak, Per Thayssen, Seppo Lehto, Jean Jacques Blanc, Franc¸ois Delahaye, Bondo Kobulia, Uwe Zeymer, Dennis Cokkinos, Kristof Karlocai, Ian Graham, Emer Shelley, Shlomo Behar, Aldo Maggioni, Lino Gonc¸alves, Virginija Grabauskiene, Inger Asmussen, Jaap Deckers, Janina Stepinska, Vyacheslav Mareev, Zorana Vasiljevic, Igor Riecansky, Miran F. Kenda, Angeles Alonso, Jose´ Luis Lopez-Sendon, Annika Rosengren, Peter Buser, Tugrul Okay, Oleg Sychov, Kevin Fox, Peter Schofield, Maarten Simoons, David Wood, Alex Battler, Eric Boersma, Kim Fox, Michel Komajda, Keith McGregor, Barbara Mulder, Sylvia Priori, Lars Ryde´n, Alec Vahanian, William Wijns, Sanofi-Aventis, S. V. Grigoryan, I. Apetyan, S. Aroyan, L. Azarapetyan, Anahit Anvari, Michael Gottsauner-Wolf, Stefan Pfaffenberger, Kadriye Aydinkoc, Karim Kalla, Martina Penka, Heinz Drexel, Peter Langer, Luc A. Pierard, Victor Legrand, Dominique Blommaert, E. Schroeder, Isabelle Mancini, P. Geelen, P. Brugada, Marc De Zutter, Christiaan Vrints, Marc Vercammen, Marielle Morissens, Boyanov Borisov, Valentin Asenov Petrov, Maria Marinova, Alexandrova Assen, Rachev Goudev, Yavor Peychev, Vassil Stoyanovsky, Evgeni Stoynev, Stjepan Kranjcevic, Joseph Moutiris, Marios Ioannides, Dominique Evequoz, Jaroslava Spacilova, Miroslav Novak, Martin Eisenberger, Jolana Mullerova, Josef Kautzner, Lucie Riedlbauchova, Jan Petru`, Milos Taborsky, Helle Cappelen, Yasser A. Sharaf, B. S.S. Ibrahim, Khalid Tammam, Aly Saad, Helmy Elghawaby, Hamed Zaky Sherif, Heba Farouk, Arlett Mielke, Markus Engelen, Paulus Kirchhof, Pia Zimmermann, F. Fernandez Aviles, Jeronimo Rubio, F. Malpartida, M. Corona, Luis Tercedor Sanchez, Jose Miguel, Lozano Herrera, Aurelio Quesada, Antonio J.Munoz Garcia, Carlos Sanchez Gonzalez, M. Soledad Alcasena Juango, Jesus Berjon-Reyero, Josep M. Alegret, J. M.Cruz Fernandez, Cesar Carrascosa, Rosillo Antonio Fernandez Romero, Miguel Gonza´lez Lara, Jose´ L.Lopez Sendon, Jose´ Juan Gomez de Diego, Luis Sosa Martin, Maria Irurita, Norbero Herrera Guttierez, Juan Ramon Siles Rubio, Isabel Antorrena, Alicia Bautista Paves, Antonio Salvador, Maria Dolores Orriach, A. Alonso Garcia, Francisco Epelde, Vicente Bertomeu Martinez, Antonio Berruezo Sanchez, Carlos Pinero Galvez, Rafael Fernandez Rivero, Antonio Hernandez Madrid, Gonzalo Baron-Esquivias, Rafael Peinado, Jose´ Antonio Gomez Guindal, Tomas Ripoll Vera, Emilio Luengo Fernandez, Ricardo Gayan, Javier Garcia, Andres Bodegas, Jesus Toril Lopez, Julio Martinez Florez, Cristobal Lozano Cabezas, Eduardo Vazquez Ruiz de Castroviejo, Juan Munoz Bellido, Maria Eugenia Ruiz, Kirsti Savolainen, Markku Nieminen, Lauri Toivonen, Mikko Syvanne, Mervi Pietila, Daniel Galley, Christine Beltra, Alain Gay, J. C. Daubert, Guillaume Lecocq, Christine Poulain, J. G.F.C. Cleland, Rhidian Shelton, A. Choudhury, Gulnara Abuladze, Irina Jashi, Anastasia Tsiavou, G. Giamouzis, N. Dagres, A. Kostopoulou, Domproglou Tsoutsanis, C. Stefanadis, George Latsios, Ioannis Vogiatzis, Alexandros Gotsis, Paraskevi Bozia, Maria Karakiriou, Spyridon Koulouris, John Parissis, George Kostakis, Nikos Kouris, Dimitra Kontogianni, Koutroubas Athanasios, Alexandros Douras, Themistoklis Tsanakis, Mary Marketou, Nikolaos Patsourakos, Laszlo Czopf, Robert Halmosi, Istvan Pre´da, Eva Csoti, Andrea Badics, Boris Strasberg, Nahum A. Freedberg, Amos Katz, Eli Zalzstein, Aviva Grosbard, E. Goldhammer, Menachem Nahir, Menashe Epstein, Ida Vider, David Luria, Lori Mandelzweig, Bruno Aloisi, Alfio Cavallaro, Emanuele Antonielli, Baldassarre Doronzo, Diego Pancaldo, Carlo Mazzola, Liliana Buontempi, Valeria Calvi, Giuseppe Giuffrida, Antonino Figlia, Francesco Ippolito, Gian Paolo Gelmini, N. Gaibazzi, Virgilio Ziacchi, Francesco De Tommasi, Federico Lombardi, Cesare Fiorentini, Paolo Terranova, Pietro Maiolino, Muhamad Albunni, Plinio Pinna-Pintor, Stefano Fumagalli, Guilio Masotti, Lorenzo Boncinelli, Domenico Rossi, Giovanni Maria Santoro, Massimo Fioranelli, Franco Naccarella, Stefano Sdringola Maranga, Giovannina Lepera, Barbara Bresciani, Elena Seragnoli, Mara Cantelli Forti, Valentina Cortina, Giacinto Baciarello, Paolo Cicconetti, Antonio Lax, Federica Vitali, Diran Igidbashian, Luisa Scarpino, Sergio Terrazzino, Luigi Tavazzi, Francesco Cantu, Francesco Pentimalli, Salvatore Novo, Giuseppe Coppola, Gianluca Zingarini, Giuseppe Ambrozio, Paolo Moruzzi, Sergio Callegari, Gabriele Saccomanno, Paolo Russo, Emanuele Carbonieri, Anna Paino, Marco Zanetta, Enzo Barducci, Roberto Cemin, Werner Rauhe, Walter Pitscheider, Marina Meloni, Sergio Mariano Marchi, Marco Di Gennaro, Sergio Calcagno, Paola Squaratti, Francesco Quartili, Patrizia Bertocchi, Mario De Martini, Giuseppe Mantovani, Roman Komorovsky, Alessandro Desideri, Leopoldo Celegon, Luigi Tarantini, Giuseppe Catania, Donata Lucci, Francesca Bianchini, Aras Puodziukynas, Ausra Kavoliuniene, Vilija Barauskiene, Audrius Aidietis, Jurate Barysiene, Vitas Vysniauskas, Irena Zukauskiene, Nijole Kazakeviciene, Ljubica Georgievska-Ismail, Lidija Poposka, Eleonora Vataman, Aurel A. Grosu, Wilma Scholte op Reimer, Esther de Swart, Mattie Lenzen, Chris Jansen, Ritzo Brons, Henriette Tebbe, D. C.A. van Hoogenhuyze, M. J. Veerhoek, Maria Kamps, D. Haan, Nitolanda van Rijn, Annette Bootsma, Leo Baur, Adrie van den, Heidi Fransen, Luc Eurlings, Joan Meeder, M. J. De Boer, Jobst Winter, Herman Broers, Chris Werter, M. Bijl, Saskia Versluis, Malgorzata Milkowska, Beata Wozakowska-Kaplon, Marianna Janion, Lidia Lepska, Grazyna Swiatecka, Piotr Kokowicz, Jacek Cybulski, Aleksandr Gorecki, Marcin Szulc, Jerzy Rekosz, Rafal Manczak, Anna Maria Wnuk-Wojnar, M. Trusz-Gluza, Anna Rybicka-Musialik, Jaroslaw Myszor, Michal Szpajer, Krzysztof Cymerman, Jerzy Sadowski, Maria Sniezek-Maciejewska, Mariola Ciesla-Dul, Izabela Gorkiewicz-Kot, Tomasz Grodzicki, Krzysztof Rewiuk, Leszek Kubik, Jacek Lewit, Joao Manuel Frazao Rodrigues de Sousa, Rafael Ferreira, Antonio Freitas, Joao Carlos Araujo Morais, Rui Pires, M. J.Veloso Gomes, Paula Gago, Rui Alexandre C. Candeias, Luis Nunes, Joao Vitor Miranda Sa, Miguel Ventura, Mario de Oliveira, Luis Brandao Alves, Ioan Bostaca, Codin T. Olariu, G. A. Dan, Anca Dan, Cristian Podoleanu, Attila Frigy, George I.M. Georgescu, Catalina Arsenescu, Cristian Statescu, Radu Sascau, Dan L. Dimitrascu, Raluca Rancea, Yuri V. Shubik, Dmitry Duplyakov, Marina Shalak, Marine Danielyan, Albert Galyavich, Venera Zakirova, Robert Hatala, Gabriela Kaliska, Jan Kmec, Igor Zupan, Jerneja Tasie`, Damijan Vokac, Nils Edvardsson, Dritan Poci, Habib Gamra, Hichem Denguir, Ahmet Sepetoglu, Alev Arat-Ozkan, Mariya Orynchak, Elena Paliy, I. Vakalyuk, David Malidze, Rostyslav Prog, Myckola Ivanovich Yabluchansky, Nataliya Volodimirovna Makienko, Tatjana Potpara, Sofija Knezevic, Miomir Randjelovic

Research output: Contribution to journalArticlepeer-review

Abstract

Hypertension is a risk factor for both progression of atrial fibrillation (AF) and development of AF-related complications, that is major adverse cardiac and cerebrovascular events (MACCE). It is unknown whether left ventricular hypertrophy (LVH) as a consequence of hypertension is also a risk factor for both these end points. We aimed to assess this in low-risk AF patients, also assessing gender-related differences. We included 799 patients from the Euro Heart Survey with nonvalvular AF and a baseline echocardiogram. Patients with and without hypertension were included. End points after 1 year were occurrence of AF progression, that is paroxysmal AF becoming persistent and/or permanent AF, and MACCE. Echocardiographic LVH was present in 33% of 379 hypertensive patients. AF progression after 1 year occurred in 10.2% of 373 patients with rhythm follow-up. In hypertensive patients with LVH, AF progression occurred more frequently as compared with hypertensive patients without LVH (23.3% vs 8.8%, p = 0.011). In hypertensive AF patients, LVH was the most important multivariably adjusted determinant of AF progression on multivariable logistic regression (odds ratio 4.84, 95% confidence interval 1.70 to 13.78, p = 0.003). This effect was only seen in male patients (27.5% vs 5.8%, p = 0.002), while in female hypertensive patients, no differences were found in AF progression rates regarding the presence or absence of LVH (15.2% vs 15.0%, p = 0.999). No differences were seen in MACCE for hypertensive patients with and without LVH. In conclusion, in men with hypertension, LVH is associated with AF progression. This association seems to be absent in hypertensive women.

Original languageEnglish
Pages (from-to)578-583
Number of pages6
JournalAmerican Journal of Cardiology
Volume122
Issue number4
DOIs
StatePublished - 15 Aug 2018

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