@article{6339805867164503b6383e1d822cdb3e,
title = "Effect of Supplemental Enteral Fish Oil on the Development of Psychological Complications in Critically Ill Multiple-Trauma Patients: 6 Months{\textquoteright} Follow-Up",
abstract = "Background: Posttraumatic stress disorder (PTSD) is common in intensive care unit (ICU) patients. Defic it intake of ω-3 polyuns aturated fatty ac ids (PUFAs) may be as sociated with developm ent of PTSD. Methods: This study randomized mechanically ventilated patients suffering from multiple trauma (n = 150) into 2 groups: a study and a control group that received enteral feeding with or without fish oil. Fifty-one patients were interviewed 6 months after discharge from the ICU. Psychometric parameters of PTSD were assessed by questionnaires. The fatty acid composition of erythrocyte membranes was performed by homogenization of the cells in hexane-isopropanol. Results: No differences were found in baseline characteristics between the groups. Erythrocyte membrane composition showed significantly higher concentrations of ω-3 fatty acids in the study group. Anxiety and depression symptoms were correlated with an increase in eicosapentaenoic acid (EPA) on days 4 and 8 for depression and EPA on day 4 and docosahexaenoic acid (DHA) on day 8 for anxiety. Total ω-3 content was positively correlated with anxiety and depression as well. An inverse correlation was found between DHA and EPA in the treatment group and with the total ω-3 and DHA in the control group for the Brief Illness Perceptions Questionnaire. Conclusion: Administration of an ω-3 PUFA–enriched diet during the ICU stay did not prevent development of PTSD in trauma patients 6 months after discharge from ICU.",
keywords = "enteral nutrition, fatty acid, omega-3, posttraumatic stress disorder, trauma",
author = "Ilya Kagan and Ronit Mesilati-Stahy and Pnina Green and Pierre Singer",
note = "Publisher Copyright: {\textcopyright} 2020 American Society for Parenteral and Enteral Nutrition",
year = "2021",
month = sep,
doi = "10.1002/jpen.2025",
language = "אנגלית",
volume = "45",
pages = "1567--1580",
journal = "Journal of Parenteral and Enteral Nutrition",
issn = "0148-6071",
publisher = "John Wiley & Sons Inc.",
number = "7",
}