Effect of Supplemental Enteral Fish Oil on the Development of Psychological Complications in Critically Ill Multiple-Trauma Patients: 6 Months’ Follow-Up

Ilya Kagan, Ronit Mesilati-Stahy, Pnina Green, Pierre Singer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Posttraumatic stress disorder (PTSD) is common in intensive care unit (ICU) patients. Defic it intake of ω-3 polyuns aturated fatty ac ids (PUFAs) may be as sociated with developm ent of PTSD. Methods: This study randomized mechanically ventilated patients suffering from multiple trauma (n = 150) into 2 groups: a study and a control group that received enteral feeding with or without fish oil. Fifty-one patients were interviewed 6 months after discharge from the ICU. Psychometric parameters of PTSD were assessed by questionnaires. The fatty acid composition of erythrocyte membranes was performed by homogenization of the cells in hexane-isopropanol. Results: No differences were found in baseline characteristics between the groups. Erythrocyte membrane composition showed significantly higher concentrations of ω-3 fatty acids in the study group. Anxiety and depression symptoms were correlated with an increase in eicosapentaenoic acid (EPA) on days 4 and 8 for depression and EPA on day 4 and docosahexaenoic acid (DHA) on day 8 for anxiety. Total ω-3 content was positively correlated with anxiety and depression as well. An inverse correlation was found between DHA and EPA in the treatment group and with the total ω-3 and DHA in the control group for the Brief Illness Perceptions Questionnaire. Conclusion: Administration of an ω-3 PUFA–enriched diet during the ICU stay did not prevent development of PTSD in trauma patients 6 months after discharge from ICU.

Original languageEnglish
Pages (from-to)1567-1580
Number of pages14
JournalJournal of Parenteral and Enteral Nutrition
Volume45
Issue number7
Early online date8 Oct 2020
DOIs
StatePublished - Sep 2021

Keywords

  • enteral nutrition
  • fatty acid
  • omega-3
  • posttraumatic stress disorder
  • trauma

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