Effect of starvation on the production and peripheral metabolism of 3,3,5́-triiodothyronine in euthyroid obese subjects

Zemach Eisenstein, S. Hagg, A. G. Vagenakis, S. L. Fang, B. Ransil, A. Burger, A. Balsam, L. E. Braverman, S. H. Ingbar

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of starvation on the peripheral metabolism of rT3 was evaluated in four obese euthyroid patients. During starvation, the serum rT3 concentration increased by 69% while the MCR of rT.i decreased in all four patients from control values of 96 ± 23 (mean ± SD) to 68 ± 17 liters/70 kg day, resulting in a slight increase in the mean production rate of rT3. These findings are in contrast to the marked decrease in T3 production rate associated with fasting, indicating that inner and outer ring deiodination of T4 can be varied independently.

Original languageEnglish
Pages (from-to)889-893
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume47
Issue number4
DOIs
StatePublished - Oct 1978
Externally publishedYes

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