Effect of starvation on the production and peripheral metabolism of 3,3,5́-triiodothyronine in euthyroid obese subjects

Zemach Eisenstein; S. Hagg; A. G. Vagenakis; S. L. Fang; B. Ransil; A. Burger; A. Balsam; L. E. Braverman; S. H. Ingbar

doi:10.1210/jcem-47-4-889

Effect of starvation on the production and peripheral metabolism of 3,3,5́-triiodothyronine in euthyroid obese subjects

Zemach Eisenstein, S. Hagg, A. G. Vagenakis, S. L. Fang, B. Ransil, A. Burger, A. Balsam, L. E. Braverman, S. H. Ingbar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The effect of starvation on the peripheral metabolism of rT₃ was evaluated in four obese euthyroid patients. During starvation, the serum rT₃ concentration increased by 69% while the MCR of rT.i decreased in all four patients from control values of 96 ± 23 (mean ± SD) to 68 ± 17 liters/70 kg day, resulting in a slight increase in the mean production rate of rT₃. These findings are in contrast to the marked decrease in T₃ production rate associated with fasting, indicating that inner and outer ring deiodination of T₄ can be varied independently.

Original language	English
Pages (from-to)	889-893
Number of pages	5
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	47
Issue number	4
DOIs	https://doi.org/10.1210/jcem-47-4-889
State	Published - Oct 1978
Externally published	Yes

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title = "Effect of starvation on the production and peripheral metabolism of 3,3,{\'5}-triiodothyronine in euthyroid obese subjects",

abstract = "The effect of starvation on the peripheral metabolism of rT3 was evaluated in four obese euthyroid patients. During starvation, the serum rT3 concentration increased by 69% while the MCR of rT.i decreased in all four patients from control values of 96 ± 23 (mean ± SD) to 68 ± 17 liters/70 kg day, resulting in a slight increase in the mean production rate of rT3. These findings are in contrast to the marked decrease in T3 production rate associated with fasting, indicating that inner and outer ring deiodination of T4 can be varied independently.",

author = "Zemach Eisenstein and S. Hagg and Vagenakis, {A. G.} and Fang, {S. L.} and B. Ransil and A. Burger and A. Balsam and Braverman, {L. E.} and Ingbar, {S. H.}",

year = "1978",

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doi = "10.1210/jcem-47-4-889",

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T1 - Effect of starvation on the production and peripheral metabolism of 3,3,5́-triiodothyronine in euthyroid obese subjects

AU - Eisenstein, Zemach

AU - Hagg, S.

AU - Vagenakis, A. G.

AU - Fang, S. L.

AU - Ransil, B.

AU - Burger, A.

AU - Balsam, A.

AU - Braverman, L. E.

AU - Ingbar, S. H.

PY - 1978/10

Y1 - 1978/10

N2 - The effect of starvation on the peripheral metabolism of rT3 was evaluated in four obese euthyroid patients. During starvation, the serum rT3 concentration increased by 69% while the MCR of rT.i decreased in all four patients from control values of 96 ± 23 (mean ± SD) to 68 ± 17 liters/70 kg day, resulting in a slight increase in the mean production rate of rT3. These findings are in contrast to the marked decrease in T3 production rate associated with fasting, indicating that inner and outer ring deiodination of T4 can be varied independently.

AB - The effect of starvation on the peripheral metabolism of rT3 was evaluated in four obese euthyroid patients. During starvation, the serum rT3 concentration increased by 69% while the MCR of rT.i decreased in all four patients from control values of 96 ± 23 (mean ± SD) to 68 ± 17 liters/70 kg day, resulting in a slight increase in the mean production rate of rT3. These findings are in contrast to the marked decrease in T3 production rate associated with fasting, indicating that inner and outer ring deiodination of T4 can be varied independently.

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JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

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Effect of starvation on the production and peripheral metabolism of 3,3,5́-triiodothyronine in euthyroid obese subjects

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