Abstract
The effect of the spleen on the efficiency of chemotherapy (cyclophosphamide) and immunotherapy (the polysaccharide levan) of C57BL mice bearing the Lewis lung carcinoma was studied. The development of Lewis lung carcinoma caused a gradual splenomegaly in the C57BL mice. Splenectomy did not, however, affect tumor growth in the nontreated host. Levan induced a pronounced splenomegaly. Splenectomy reduced markedly the antitumoral effect of the polysaccharide. These results indicate that spleen elements participate in the inhibitory activity of levan. By contrast, splenectomy had no effect on the efficiency of treatment of cyclophosphamide.
| Original language | English |
|---|---|
| Pages (from-to) | 268-271 |
| Number of pages | 4 |
| Journal | Journal of Surgical Oncology |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1987 |
Keywords
- cancer treatment
- cyclophosphamide
- levan
- splenectomy
