Effect of six months of growth hormone therapy, followed by treatment withdrawal in short children with normal quantitative indexes of growth hormone secretion

S. A. Chalew; M. Phillip; A. A. Kowarski

doi:10.1016/S0022-3476(96)70083-5

Effect of six months of growth hormone therapy, followed by treatment withdrawal in short children with normal quantitative indexes of growth hormone secretion

S. A. Chalew^*
, M. Phillip
, A. A. Kowarski

^*Corresponding author for this work

University of Maryland, Baltimore

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Eight short patients with normal 24-hour integrated concentration of growth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is associated with supraphysiologic IC-GH after injection.

Original language	English
Pages (from-to)	456-458
Number of pages	3
Journal	Journal of Pediatrics
Volume	129
Issue number	3
DOIs	https://doi.org/10.1016/S0022-3476(96)70083-5
State	Published - 1996
Externally published	Yes

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title = "Effect of six months of growth hormone therapy, followed by treatment withdrawal in short children with normal quantitative indexes of growth hormone secretion",

abstract = "Eight short patients with normal 24-hour integrated concentration of growth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is associated with supraphysiologic IC-GH after injection.",

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AU - Phillip, M.

AU - Kowarski, A. A.

PY - 1996

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N2 - Eight short patients with normal 24-hour integrated concentration of growth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is associated with supraphysiologic IC-GH after injection.

AB - Eight short patients with normal 24-hour integrated concentration of growth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is associated with supraphysiologic IC-GH after injection.

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ER -

Effect of six months of growth hormone therapy, followed by treatment withdrawal in short children with normal quantitative indexes of growth hormone secretion

Abstract

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