TY - JOUR
T1 - Effect of six months of growth hormone therapy, followed by treatment withdrawal in short children with normal quantitative indexes of growth hormone secretion
AU - Chalew, S. A.
AU - Phillip, M.
AU - Kowarski, A. A.
PY - 1996
Y1 - 1996
N2 - Eight short patients with normal 24-hour integrated concentration of growth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is associated with supraphysiologic IC-GH after injection.
AB - Eight short patients with normal 24-hour integrated concentration of growth hormone by continuous withdrawal (IC-GH) received 6 months of GH therapy, followed by 6 months off. GH therapy increased growth rate (+2.9 cm/yr), repeated IC-GH (sixfold), and IGF-1 concentration (twofold). Posttreatment growth reverted to the pretreatment rate. Thus increased growth rate and IGF-1 concentration is associated with supraphysiologic IC-GH after injection.
UR - http://www.scopus.com/inward/record.url?scp=0030377899&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(96)70083-5
DO - 10.1016/S0022-3476(96)70083-5
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C2 - 8804340
AN - SCOPUS:0030377899
SN - 0022-3476
VL - 129
SP - 456
EP - 458
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 3
ER -