Effect of short-term hyperthyroxinemia on vitamin D metabolism in congenital hypothyroidism

J. Laufer, D. Noff, S. Orda, J. Sack

Research output: Contribution to journalArticlepeer-review

Abstract

The circulating concentrations of vitamin D metabolites were measured in nine children (four to ten years of age) with congenital hypothyroidism on L-thyroxine therapy, before and after a short term increase (33%) in dosage. The concentrations of 25-hydroxy vitamin D and 24,25-dihydroxy vitamin D were not altered, but the concentration of 1,25 dihydroxyvitamin D was significantly higher in the serum of the children after three weeks of hyperthyroxinemia. This was associated with an increase in urinary calcium excretion. The increases in serum concentration of 1,25 dihydroxy vitamin D cannot be explained by differences in serum levels of calcium, phosphorus or parathyroid hormone. These findings differ from data obtained in adults.

Original languageEnglish
Pages (from-to)386-388
Number of pages3
JournalHormone and Metabolic Research
Volume25
Issue number7
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • L-thyroxine therapy
  • congenital hypothyroidism
  • vitamin D

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